Relation Results

Summary

Name SCN8A
Full Name Sodium channel protein type 8 subunit alpha
Synonyms Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6 | MED
Primary ID Q9UQD0
Links - -
Type protein
Relations 27
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066). Assuming opened or closed conformations in response t ...
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Type: Score: Layout: SPV 
0.2820.2790.2720.2710.20.550.20.20.3180.20.2540.4520.3260.4080.4530.70.80.452CAMK2DSCN8ACAMK2ACAMK2BCAMK2GGSK3BFGF14ESR1IL10FGF12TNFFGF11CALM3NEDD4LFGF13CALM1Action_potential sodium(1+)CALM2

Modifications Tables

Relations

Regulator
Mechanism
target
score
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.282
Identifier Residue Sequence Organism Cell Line
SIGNOR-275790 Ser561 PFLSRHNsKSSIFSF Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275791 Ser641 RRSVKRNsTVDCNGV Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275792 Thr642 RSVKRNStVDCNGVV Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.279
Identifier Residue Sequence Organism Cell Line
SIGNOR-275784 Ser561 PFLSRHNsKSSIFSF Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275785 Ser641 RRSVKRNsTVDCNGV Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275786 Thr642 RSVKRNStVDCNGVV Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.272
Identifier Residue Sequence Organism Cell Line
SIGNOR-275787 Ser561 PFLSRHNsKSSIFSF Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275788 Ser641 RRSVKRNsTVDCNGV Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275789 Thr642 RSVKRNStVDCNGVV Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.271
Identifier Residue Sequence Organism Cell Line
SIGNOR-275793 Ser561 PFLSRHNsKSSIFSF Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275794 Ser641 RRSVKRNsTVDCNGV Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275795 Thr642 RSVKRNStVDCNGVV Homo sapiens Neuron
pmid sentence
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability|mmobilized peptide arrays and nanoflow LC-electrospray ionization/MS of Nav1.6 reveal potential sites of CaMKII phosphorylation, specifically Ser-561 and Ser-641/Thr-642 within the first intracellular loop of the channel.
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN8A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275763 Thr1938 HREKKEStPSTASLP Rattus norvegicus Neuron
pmid sentence
In vivo genetic manipulations demonstrate that GSK3β and Nav1.6 are molecular determinants of MSN excitability and that silencing of GSK3β prevents maladaptive plasticity of IC MSNs. In vitro studies reveal direct interaction of GSK3β with Nav1.6 and phosphorylation at Nav1.6T1936 by GSK3β. A GSK3β-Nav1.6T1936 competing peptide reduces MSNs excitability in IC, but not EC rats. These results identify GSK3β regulation of Nav1.6 as a biosignature of MSNs maladaptive plasticity.
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.55
Identifier Residue Sequence Organism Cell Line
SIGNOR-253413 Homo sapiens Neuron
pmid sentence
Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels.
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN8A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253476 Mus musculus Neuron
pmid sentence
In this study, quantitative real-time PCR analysis showed that the gene expression levels of TTX-S (Nav1.1 and Nav1.7) and TTX-R (Nav1.8 and Nav1.9) sodium channel subtypes were elevated in DRGs of αERKO and βERKO mice, whereas Nav1.6 mRNA decreased in αERKOs but showed no changes in βERKO mice
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN8A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253501 Rattus norvegicus Neuron
pmid sentence
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α.
Publications: 1 Organism: Rattus Norvegicus
Tissue: Spinal Ganglion
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-253412 Homo sapiens Neuron
pmid sentence
Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels.
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN8A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253482 Mus musculus Cerebral Cortical Neuron
pmid sentence
TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels.
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png SCN8A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253491 Mus musculus Cerebral Cortical Neuron
pmid sentence
TNF-α increases Na(+) currents by accelerating the channel activation as well as increasing the expression of VGSCs in a mechanism dependent upon NF-κB and p38 MAPK signal pathways in CNS neurons. TNF-α increased Na(+) currents by accelerating the activation of VGSCs. The threshold for action potential (AP) was decreased and firing rate were increased. VGSCs were up-regulated at both the mRNA and protein levels.
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-253414 Homo sapiens Neuron
pmid sentence
Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels.
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.452
Identifier Residue Sequence Organism Cell Line
SIGNOR-266346 Homo sapiens
pmid sentence
Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias.
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SCN8A 0.326
Identifier Residue Sequence Organism Cell Line
SIGNOR-253461 Mus musculus Neuron
pmid sentence
The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2).
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.408
Identifier Residue Sequence Organism Cell Line
SIGNOR-253411 Homo sapiens Neuron
pmid sentence
Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels.
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.453
Identifier Residue Sequence Organism Cell Line
SIGNOR-253410 Homo sapiens
pmid sentence
Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Action_potential 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-253452 Homo sapiens
pmid sentence
The expression of voltage-gated sodium channels (NaVs) is a key feature for initiation and conduction of action potentials in excitable tissues and cells such as cardiac and skeletal muscle and neurons.
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization sodium(1+) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-253406 Homo sapiens
pmid sentence
Voltage-gated Na1 channels (NaV channels) drive the rapid upstroke of action potentials in cardiac and skeletal muscle and in most neurons, thereby serving as initiators of electrical activity in excitable tissue. Nine genes encode a family of homologous of NaV channel pore-forming a subunits. While channels are open, Na1 ions flux through the central pore down an electrochemical gradient, further depolarizing the membrane and triggering an action potential.
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.452
Identifier Residue Sequence Organism Cell Line
SIGNOR-266330 Homo sapiens Neuron
pmid sentence
Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias.
Publications: 1 Organism: Homo Sapiens
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