Relation Results

Summary

Name PIKFYVE
Full Name 1-phosphatidylinositol 3-phosphate 5-kinase
Synonyms Phosphatidylinositol 3-phosphate 5-kinase, FYVE finger-containing phosphoinositide kinase, PIKfyve, Phosphatidylinositol 3-phosphate 5-kinase type III, PIPkin-III, Type III PIP kinase | KIAA0981, PIP5K3
Primary ID Q9Y2I7
Links - -
Type protein
Relations 4
Function Dual specificity kinase implicated in myriad essential cellular processes such as maintenance of endomembrane homeostasis, and endocytic-vacuolar path ...
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Type: Score: Layout: SPV 
0.4970.20.20.934AKT1PIKFYVEAKTAMPKPAS complex

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKT1up-regulates img/direct-activation.png phosphorylation PIKFYVE 0.497
Identifier Residue Sequence Organism Cell Line
SIGNOR-252474 Ser307 PARNRSAsITNLSLD Homo sapiens
pmid sentence
Here we report that serine318 on the fyve domain-containing ptdins3p 5-kinase (pikfyve) is a novel substrate for pkb, and show that phosphorylation stimulates the ptdins3p 5-kinase activity of the enzyme.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ AKTup-regulates img/direct-activation.png phosphorylation PIKFYVE 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-130920 Ser307 PARNRSAsITNLSLD Homo sapiens
pmid sentence
Here we report that serine318 on the fyve domain-containing ptdins3p 5-kinase (pikfyve) is a novel substrate for pkb, and show that phosphorylation stimulates the ptdins3p 5-kinase activity of the enzyme.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ AMPKup-regulates activity img/direct-activation.png phosphorylation PIKFYVE 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263031 Ser307 PARNRSAsITNLSLD in vitro
pmid sentence
AMPK phosphorylated PIKfyve at Ser307 both in vitro and in intact cells. We propose that PIKfyve activity is required for the stimulation of skeletal muscle glucose uptake by contraction/AMPK activation. PIKfyve is a new AMPK substrate whose phosphorylation at Ser307 could promote PIKfyve translocation to endosomes for PtdIns(3,5)P2 synthesis to facilitate GLUT4 (glucose transporter 4) translocation.
Publications: 1 Organism: In Vitro
+ PIKFYVEform complex img/form-complex.png binding PAS complex 0.934
Identifier Residue Sequence Organism Cell Line
SIGNOR-253529 Homo sapiens HEK-293 Cell
pmid sentence
Here we have identified and characterized Sac3, a Sac domain phosphatase, as the Fig4 mammalian counterpart. Endogenous Sac3, a widespread 97-kDa protein, formed a stable ternary complex with ArPIKfyve and PIKfyve. Sac3 assembles with PIKfyve and ArPIKfyve in a stable ternary complex and controls PtdIns(3,5)P2 levels.
Publications: 1 Organism: Homo Sapiens
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