Summary

Name SIK3
Full Name Serine/threonine-protein kinase SIK3
Synonyms Salt-inducible kinase 3, SIK-3, Serine/threonine-protein kinase QSK | KIAA0999, QSK
Primary ID Q9Y2K2
Links - -
Type protein
Relations 4
Function Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation CRTC2 0.618
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SIK3 0.463
Publications: 1 Organism: Homo Sapiens