Summary

Name GIT1
Full Name ARF GTPase-activating protein GIT1
Synonyms ARF GAP GIT1, Cool-associated and tyrosine-phosphorylated protein 1, CAT-1, CAT1, G protein-coupled receptor kinase-interactor 1, GRK-interacting protein 1
Primary ID Q9Y2X7
Links - -
Type protein
Relations 5
Function GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation GIT1 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP2K1 0.406
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GIT1 0.414
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ARHGEF6 0.845
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PLCG1 0.532
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle