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3.0
The SIGnaling Network
Open Resource
3.0
Signor is a resource that annotates experimental evidence about causal interactions between proteins and other entities of biological relevance: stimuli, phenotypes, enzyme inhibitors, complexes, protein families etc. Each entry points to the experimental evidence supporting the interaction and is enriched by additional relevant metadata such as the effect of the interaction on the activity of the target entity, the molecular mechanism underlying this effect, etc… The curated data can be displayed as signed directed graphs by a graph drawing tool.
This new release, Signor 3.0, aside from offering a large increment in curated entries, includes a number of additional improvements. The layout of the web pages has been changed to offer a fresher and cleaner appearance and a smoother navigation. New graph tools have been added to facilitate analysis. A more powerful search tool now allows more detailed queries.
A major advance of this release is represented by the development of a new strategy for assigning the relevance score to each interaction. The new scoring system performs better in inferring the biological relevance of interactions in a golden standard.
The SIGNOR project was supported by the Italian Association for Cancer Research and by Human Technopole (please visit link).
SIGNOR is currently supported by the joint collarboration of the University of Rome "Tor Vergata" and the Sapienza University of Rome.
Lo Surdo P, Iannuccelli M, Contino S, Castagnoli L, Licata L, Cesareni G, Perfetto L. SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update. Nucleic Acids Res. 2022 Oct 16:gkac883. doi: 10.1093/nar/gkac883. Epub ahead of print. PMID: 36243968.
This work is licensed under Creative Commons Attribution 4.0 International
