ABOUT

Signor is a resource that annotates experimental evidence about causal interactions between proteins and other entities of biological relevance: stimuli, phenotypes, enzyme inhibitors, complexes, protein families etc. Each entry points to the experimental evidence supporting the interaction and is enriched by additional relevant metadata such as the effect of the interaction on the activity of the target entity, the molecular mechanism underlying this effect, etc… The curated data can be displayed as signed directed graphs by a graph drawing tool.

SIGNOR 4.0 delivers a substantial expansion of curated content together with several targeted enhancements. This release introduces PhosphoSIGNOR, a dedicated search interface for phosphorylation events and annotations, and includes improvements to the curation environment and quality-control procedures to ensure greater consistency and reliability. These updates strengthen the resource and broaden the analytical possibilities for users.

The SIGNOR project was supported by the Italian Association for Cancer Research and by Human Technopole (please visit link).

SIGNOR is currently supported by the joint collarboration of the University of Rome "Tor Vergata" and the Sapienza University of Rome.

Citing SIGNOR

Lo Surdo P, Iannuccelli M, Karis K, Meo E, Omidi P, Tosoni M, Graziosi S, Panni S, Fiorillo MT, Licata L, Sacco F, Gyori BM, Perfetto L. SIGNOR 4.0: the 2025 update with focus on phosphorylation data. Nucleic Acids Res. 2025 Nov 17:gkaf1237. doi: 10.1093/nar/gkaf1237. Epub ahead of print. PMID: 41243950.

License

SIGNOR 3.0 is licensed under Creative Commons Attribution 4.0 International

SIGNOR Scientific Advisory Board (SAB)

The SIGNOR Scientific Advisory Board (SAB) plays a crucial role in shaping the development and future direction of the SIGNOR database. Comprising leading experts in the field, the SAB provides strategic guidance and critical insights to ensure the database remains at the forefront of scientific research. The SAB’s contributions help maintain the quality, relevance, and innovation of SIGNOR, ensuring it continues to be a valuable resource for the scientific community.

The members of the SAB are: