Relation Results

Summary

Name 2'-3'-cGAMP(2-)
Synonyms 2',3'-cGAMP (UniProt), 2'-3'-cyclic GMP-AMP(2-) (SUBMITTER), cyclic G(2'-5')pA(3'-5')p(2-) (ChEBI)
IUPAC
Formula C20H22N10O13P2
Primary ID CHEBI:143093
Type small molecule
Relations 4

Viewer

Type: Score: Layout: SPV 
0.80.80.80.8ATP(4-)2'-3'-cGAMP(2-)CGASSTING1GTP(4-)

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ ATP(4-)up-regulates quantity img/direct-activation.png precursor of 2'-3'-cGAMP(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-276594
pmid sentence
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family.
Publications: 1
+ CGASup-regulates quantity img/direct-activation.png chemical modification 2'-3'-cGAMP(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-276593
pmid sentence
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family.
Publications: 1
+ 2'-3'-cGAMP(2-)up-regulates activity img/direct-activation.png binding STING1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-276596
pmid sentence
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family.
Publications: 1
+ GTP(4-)up-regulates quantity img/direct-activation.png precursor of 2'-3'-cGAMP(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-276595
pmid sentence
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family.
Publications: 1
a simple tooltip