| + |
CGAS | up-regulates quantity
chemical modification
|
2'-3'-cGAMP(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276593 |
|
|
|
|
| pmid |
sentence |
| 23258413 |
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family. |
|
| Publications: |
1 |
| + |
2'-3'-cGAMP(2-) | up-regulates activity
binding
|
STING1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276596 |
|
|
|
|
| pmid |
sentence |
| 23258413 |
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family. |
|
| Publications: |
1 |
| + |
GTP(4-) | up-regulates quantity
precursor of
|
2'-3'-cGAMP(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276595 |
|
|
|
|
| pmid |
sentence |
| 23258413 |
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family. |
|
| Publications: |
1 |
| + |
ATP(4-) | up-regulates quantity
precursor of
|
2'-3'-cGAMP(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276594 |
|
|
|
|
| pmid |
sentence |
| 23258413 |
Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and activates the adaptor protein STING. Through biochemical fractionation and quantitative mass spectrometry, we identified a cGAMP synthase (cGAS), which belongs to the nucleotidyltransferase family. |
|
| Publications: |
1 |