Relation Results

Summary

Name 18-hydroxycorticosterone
Synonyms 18-Hydroxycorticosterone (KEGG COMPOUND), 18-hydroxycorticosterone (UniProt)
IUPAC 11beta,18,21-trihydroxypregn-4-ene-3,20-dione
Formula C21H30O5
Primary ID CHEBI:16485
Type small molecule
Relations 3
Pathways Sex Hormone Biosynthesis

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Type: Score: Layout: SPV 
0.80.80.8CYP11B218-hydroxycorticosteronecorticosteronealdosterone

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Relations
Regulator
Mechanism
target
score ℹ
+ CYP11B2up-regulates quantity img/direct-activation.png chemical modification 18-hydroxycorticosterone 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268684 Homo sapiens
pmid sentence
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Glomerulosa
Pathways:Sex Hormone Biosynthesis
+ corticosteroneup-regulates quantity img/direct-activation.png precursor of 18-hydroxycorticosterone 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268674 Homo sapiens
pmid sentence
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Glomerulosa
Pathways:Sex Hormone Biosynthesis
+ 18-hydroxycorticosteroneup-regulates quantity img/direct-activation.png precursor of aldosterone 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268686 Homo sapiens
pmid sentence
The zona glomerulosa lacks the 17alpha-hydroxylase enzyme, committing pregnenolone to the exclusive production of aldosterone.|In the adrenal steroidogenic pathway, 21-hydroxylase (P450c21) catalyzes the conversion of 17-hydroxyprogesterone (17OHP) to 11-deoxycortisol to form cortisol and the conversion of progesterone to 11-deoxycorticosterone to form aldosterone
Publications: 1 Organism: Homo Sapiens
Tissue: Zona Glomerulosa
Pathways:Sex Hormone Biosynthesis
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