Relation Results

Summary

Name IMP
Synonyms 2'-inosine-5'-monophosphate (ChEBI), 5'-IMP (KEGG COMPOUND), 5'-Inosinate (KEGG COMPOUND), 5'-Inosine monophosphate (KEGG COMPOUND), 5'-Inosinic acid (KEGG COMPOUND), hypoxanthosine 5'-monophosphate (ChEBI), IMP (KEGG COMPOUND), Inosine 5'-monophosphate (KEGG COMPOUND), Inosine 5'-phosphate (KEGG COMPOUND), Inosine monophosphate (KEGG COMPOUND), Inosinic acid (KEGG COMPOUND), inosinic acid (PDBeChem), ribosylhypoxanthine monophosphate (MetaCyc)
IUPAC 5'-inosinic acid
Formula C10H13N4O8P
Primary ID CHEBI:17202
Type small molecule
Relations 11
Pathways Nucleotide Biosynthesis

Viewer

Type: Score: Layout: SPV 
0.80.80.80.80.80.80.80.80.80.85-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)IMPADSS1ATICadenosine 5'-monophosphate5'-xanthylic acidADSS2GDPIMPDH2IMPDH1AMPD1

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)up-regulates quantity img/direct-activation.png precursor of IMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267328 Homo sapiens
pmid sentence
The last two steps in the pathway are catalyzed by the bifunctional AICAR transformylase/IMP cyclohydrolase (ATIC). The transformylase domain of the enzyme first catalyzes the conversion of AICAR to formylaminoimida zole-4-carboxamide ribonucleotide (FAICAR) using the N10-formyltetrahydrofolate. Then, the cyclohydrolase domain closes the purine ring to form IMP.
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ ADSS1down-regulates quantity img/direct_inhibition.png chemical modification IMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267344 Homo sapiens
pmid sentence
Adenylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from l-aspartate and IMP.
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ ATICup-regulates quantity img/direct-activation.png chemical modification IMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267329 Homo sapiens
pmid sentence
The last two steps in the pathway are catalyzed by the bifunctional AICAR transformylase/IMP cyclohydrolase (ATIC). The transformylase domain of the enzyme first catalyzes the conversion of AICAR to formylaminoimida zole-4-carboxamide ribonucleotide (FAICAR) using the N10-formyltetrahydrofolate. Then, the cyclohydrolase domain closes the purine ring to form IMP.
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ adenosine 5'-monophosphateup-regulates quantity img/direct-activation.png precursor of IMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269774 Homo sapiens
pmid sentence
AMP deaminase (AMPD; EC 3.5.4.6) is encoded by a multigene family in mammals. The AMPD1 gene is expressed at high levels in skeletal muscle, where this enzyme is thought to play an important role in energy metabolism. AMP deaminase (AMPD; EC 3.5.4.6), an enzyme that catalyzes deamination of AMP to IMP, and the purine nucleotide cycle, of which AMPD is one component, play a central role in purine nucleotide interconversion in eukaryotic cells.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ IMPup-regulates quantity img/direct-activation.png precursor of 5'-xanthylic acid 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267333 Homo sapiens
pmid sentence
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS).
Identifier Residue Sequence Organism Cell Line
SIGNOR-267330 Homo sapiens
pmid sentence
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. Humans and other mammals have two IMPDH genes, encoding hIMPDH1 and hIMPDH2. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS).
Publications: 2 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ ADSS2down-regulates quantity img/direct_inhibition.png chemical modification IMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267343 Homo sapiens
pmid sentence
Adenylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from l-aspartate and IMP.
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ IMPup-regulates quantity img/direct-activation.png precursor of GDP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-268130
pmid sentence
Adenylosuccinate synthetase catalyzes the first committed step in the de novo biosynthesis of AMP, thermodynamically coupling the hydrolysis of GTP to the formation of adenylosuccinate from l-aspartate and IMP.
Publications: 1
Pathways:Nucleotide Biosynthesis
+ IMPDH2down-regulates quantity img/direct_inhibition.png chemical modification IMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267334 Homo sapiens
pmid sentence
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS).
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ IMPDH1down-regulates quantity img/direct_inhibition.png chemical modification IMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267331 Homo sapiens
pmid sentence
IMPDH controls the gateway to guanine nucleotides, making it an “enzyme of consequence” for virtually every organism. The IMPDH-catalyzed conversion of IMP to XMP is the first committed and rate-limiting step in guanine nucleotide biosynthesis. XMP is subsequently converted to GMP by the action of GMP synthetase (GMPS).
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ AMPD1up-regulates quantity img/direct-activation.png chemical modification IMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269773 Homo sapiens
pmid sentence
AMP deaminase (AMPD; EC 3.5.4.6) is encoded by a multigene family in mammals. The AMPD1 gene is expressed at high levels in skeletal muscle, where this enzyme is thought to play an important role in energy metabolism. AMP deaminase (AMPD; EC 3.5.4.6), an enzyme that catalyzes deamination of AMP to IMP, and the purine nucleotide cycle, of which AMPD is one component, play a central role in purine nucleotide interconversion in eukaryotic cells.
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
a simple tooltip