| + |
ribosomal RNA | form complex 
binding
|
B-WICH complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269470 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21559432 |
The B-WICH complex is an extended form of WICH [26], and is involved in both RNA pol I and RNA pol III transcription [20], [21]. In addition to the three core proteins, WSTF, SNF2h, and nuclear myosin (NM1); the myb binding protein 1b, RNA helicase II/DXX21, and SAP155 all also associate via RNA species [21]. The subunit SNF2h is an ISWI ATPase, which slides nucleosomes in an ATP-dependent manner [27]. WSTF is a component of several complexes: two SNF2h complexes, B-WICH [21] and WICH [26], and one SWI/SNF type of chromatin remodelling complex, the WINAC complex, which is involved in vitamin D-mediated RNA pol II transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ribonuclease MRP complex | up-regulates quantity 
chemical modification
|
ribosomal RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40413743 |
Human RNase MRP is a ribonucleoprotein (RNP) enzyme that processes precursor rRNA (pre-rRNA) at ITS1 site 2 and may have additional activities.Using a genome-wide forward genetic screening that leveraged the requirement of RNase MRP and RNase P for reporter translation, we identified two poorly characterized yet highly enriched human genes, c18orf21 and c3orf17, which we named ribonuclease MRP subunit P24 (RMP24) and RMP64, respectively. We demonstrate that these two genes are specifically required for the activity of human RNase MRP but not RNase P. The protein products of RMP24 and RMP64 associate extensively and exclusively with the only known human RNase MRP-specific component, MRP RNA, but not with the RNase P-specific H1 RNA. Our findings establish Rmp24 and Rmp64 as human protein components unique to RNase MRP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
U3 snoRNP | up-regulates quantity
binding
|
ribosomal RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280833 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29414516 |
The small subunit processome is the first precursor of the small eukaryotic ribosomal subunit. Eukaryotic ribosome biogenesis is initiated by the seven-subunit UtpA complex (Utp4, Utp5, Utp8, Utp9, Utp10, Utp15 & Utp17). UtpA binding and the presence of additional parts of the 5′ ETS appear to be required for the subsequent recruitment of the six-subunit UtpB complex (Utp1/Pwp2, Utp6, Utp12, Utp13, Utp18 & Utp21) and the U3 snoRNP (U3 snoRNA, Nop1/fibrillarin, Snu13, Nop56 & Nop58) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UTP-A complex | up-regulates quantity
binding
|
ribosomal RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280834 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29414516 |
The small subunit processome is the first precursor of the small eukaryotic ribosomal subunit. Eukaryotic ribosome biogenesis is initiated by the seven-subunit UtpA complex (Utp4, Utp5, Utp8, Utp9, Utp10, Utp15 & Utp17). UtpA binding and the presence of additional parts of the 5′ ETS appear to be required for the subsequent recruitment of the six-subunit UtpB complex (Utp1/Pwp2, Utp6, Utp12, Utp13, Utp18 & Utp21) and the U3 snoRNP (U3 snoRNA, Nop1/fibrillarin, Snu13, Nop56 & Nop58) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
UTP-B complex | up-regulates quantity
binding
|
ribosomal RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280835 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29414516 |
The small subunit processome is the first precursor of the small eukaryotic ribosomal subunit. Eukaryotic ribosome biogenesis is initiated by the seven-subunit UtpA complex (Utp4, Utp5, Utp8, Utp9, Utp10, Utp15 & Utp17). UtpA binding and the presence of additional parts of the 5′ ETS appear to be required for the subsequent recruitment of the six-subunit UtpB complex (Utp1/Pwp2, Utp6, Utp12, Utp13, Utp18 & Utp21) and the U3 snoRNP (U3 snoRNA, Nop1/fibrillarin, Snu13, Nop56 & Nop58) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RNA Polymerase I | up-regulates quantity
chemical modification
|
ribosomal RNA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22260999 |
In eukaryotic cells, the RNA polymerase Pol I synthesizes the rRNA precursor, Pol II transcribes mRNAs and small non-coding RNAs (such as small nuclear RNAs), and Pol III produces tRNAs and other small RNAs. Pol I, II and II contain 14, 12 and 17 polypeptide subunits, respectively (Table 1).  |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Transcription initiation |
4.0
ribosomal RNA