| + |
succinyl-CoA(5-) | up-regulates quantity 
precursor of
|
succinate(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266265 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27487822 |
In the citric acid cycle, succinyl-CoA synthetase (SCS) catalyzes the only step that provides substrate-level phosphorylation: succinyl-CoA + NDP + Pi = succinate + CoA + NTP, where N is adenosine or guanosine and the reaction requires magnesium ions. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266266 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27487822 |
In the citric acid cycle, succinyl-CoA synthetase (SCS) catalyzes the only step that provides substrate-level phosphorylation: succinyl-CoA + NDP + Pi = succinate + CoA + NTP, where N is adenosine or guanosine and the reaction requires magnesium ions. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
(S)-methylmalonyl-CoA(5-) | up-regulates quantity
precursor of
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269110 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1978672 |
Methylmalonyl-CoA mutase (MCM) is an adenosylcobalamin-dependent enzyme that catalyses isomerization between methylmalonyl-CoA and succinyl-CoA (3-carboxypropionyl-CoA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Succinyl-CoA ATP variant | down-regulates quantity 
chemical modification
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266267 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27487822 |
In the citric acid cycle, succinyl-CoA synthetase (SCS) catalyzes the only step that provides substrate-level phosphorylation: succinyl-CoA + NDP + Pi = succinate + CoA + NTP, where N is adenosine or guanosine and the reaction requires magnesium ions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
2-oxoglutarate(2-) | up-regulates quantity
precursor of
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15953811 |
The α-ketoglutarate–dehydrogenase complex is a complex including multiple copies of three proteins: E1k (α-ketoglutarate dehydrogenase), E2k (dihydrolipoyl succinyltransferase), and E3 (dihydrolipoamide dehydrogenase) (Fig. 2). The consecutive action of the three catalytic components of KGDHC results in oxidative decarboxylation of 2-oxoglutarate, preserving the energy in the form of succinylCoA and NADH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
MMUT | up-regulates quantity
chemical modification
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269109 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1978672 |
Methylmalonyl-CoA mutase (MCM) is an adenosylcobalamin-dependent enzyme that catalyses isomerization between methylmalonyl-CoA and succinyl-CoA (3-carboxypropionyl-CoA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
succinyl-CoA(5-) | up-regulates quantity
precursor of
|
coenzyme A(4-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271805 |
|
|
|
|
| pmid |
sentence |
| 33148467 |
The acyl-CoA thioesterase (ACOT) family catalyses the hydrolysis of acyl-CoA thioesters to their corresponding non-esterified fatty acid and coenzyme A (CoA). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271808 |
|
|
|
|
| pmid |
sentence |
| 33148467 |
The acyl-CoA thioesterase (ACOT) family catalyses the hydrolysis of acyl-CoA thioesters to their corresponding non-esterified fatty acid and coenzyme A (CoA). |
|
| Publications: |
2 |
| + |
ACOT8 | down-regulates quantity
chemical modification
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271810 |
|
|
|
|
| pmid |
sentence |
| 33148467 |
The acyl-CoA thioesterase (ACOT) family catalyses the hydrolysis of acyl-CoA thioesters to their corresponding non-esterified fatty acid and coenzyme A (CoA). |
|
| Publications: |
1 |
| + |
OGDC | up-regulates quantity
chemical modification
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266258 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15953811 |
The α-ketoglutarate–dehydrogenase complex is a complex including multiple copies of three proteins: E1k (α-ketoglutarate dehydrogenase), E2k (dihydrolipoyl succinyltransferase), and E3 (dihydrolipoamide dehydrogenase) (Fig. 2). The consecutive action of the three catalytic components of KGDHC results in oxidative decarboxylation of 2-oxoglutarate, preserving the energy in the form of succinylCoA and NADH. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
| + |
ACOT4 | down-regulates quantity
chemical modification
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271807 |
|
|
|
|
| pmid |
sentence |
| 33148467 |
The acyl-CoA thioesterase (ACOT) family catalyses the hydrolysis of acyl-CoA thioesters to their corresponding non-esterified fatty acid and coenzyme A (CoA). |
|
| Publications: |
1 |
| + |
Succinyl-CoA GTP variant | down-regulates quantity
chemical modification
|
succinyl-CoA(5-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266268 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27487822 |
In the citric acid cycle, succinyl-CoA synthetase (SCS) catalyzes the only step that provides substrate-level phosphorylation: succinyl-CoA + NDP + Pi = succinate + CoA + NTP, where N is adenosine or guanosine and the reaction requires magnesium ions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Citric acid cycle |
3.0
succinyl-CoA(5-)