Relation Results

Summary

Name orotidine 5'-phosphate(3-)
Synonyms 6-carboxylato-5'-O-phosphonatouridine (ChEBI), orotidine 5'-phosphate (UniProt), orotidine 5'-phosphate trianion (ChEBI)
IUPAC 2,6-dioxo-3-(5-O-phosphonato-beta-D-ribofuranosyl)-1,2,3,6-tetrahydropyrimidine-4-carboxylate
Formula C10H10N2O11P
Primary ID CHEBI:57538
Type small molecule
Relations 5
Pathways Nucleotide Biosynthesis

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Type: Score: Layout: SPV 
0.80.80.80.85-phospho-α-D-ribose 1-diphosphateorotidine 5'-phosphate(3-)UMPUMPSorotate

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Relations
Regulator
Mechanism
target
score ℹ
+ 5-phospho-α-D-ribose 1-diphosphateup-regulates quantity img/direct-activation.png precursor of orotidine 5'-phosphate(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267435 Homo sapiens
pmid sentence
Uridine 5'-phosphate (UMP) synthase contains two sequential catalytic activities for the synthesis of orotidine 5'-phosphate (OMP) from orotate (EC 2.4.2.10, orotate phosphoribosyltransferase) and the decarboxylation of OMP to form UMP (EC 4.1.1.23, OMP decarboxylase).
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ orotidine 5'-phosphate(3-)up-regulates quantity img/direct-activation.png precursor of UMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267439 Homo sapiens
pmid sentence
Uridine 5'-phosphate (UMP) synthase contains two sequential catalytic activities for the synthesis of orotidine 5'-phosphate (OMP) from orotate (EC 2.4.2.10, orotate phosphoribosyltransferase) and the decarboxylation of OMP to form UMP (EC 4.1.1.23, OMP decarboxylase).
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ UMPSdown-regulates quantity img/direct_inhibition.png chemical modification orotidine 5'-phosphate(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-253581 Homo sapiens
pmid sentence
Orotate phosphoribosyltransferase (OPRTase, EC 2.4.2.10) catalyzes the Mg2+-dependent condensation of orotic acid (OA) with PRPP (5-alpha-d-phosphorylribose 1-diphosphate) to yield diphosphate (PPi) and the nucleotide OMP (orotidine 5'-monophosphate).
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ UMPSup-regulates quantity img/direct-activation.png chemical modification orotidine 5'-phosphate(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267438 Homo sapiens
pmid sentence
Uridine 5'-phosphate (UMP) synthase contains two sequential catalytic activities for the synthesis of orotidine 5'-phosphate (OMP) from orotate (EC 2.4.2.10, orotate phosphoribosyltransferase) and the decarboxylation of OMP to form UMP (EC 4.1.1.23, OMP decarboxylase).
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
+ orotateup-regulates quantity img/direct-activation.png precursor of orotidine 5'-phosphate(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267434 Homo sapiens
pmid sentence
Uridine 5'-phosphate (UMP) synthase contains two sequential catalytic activities for the synthesis of orotidine 5'-phosphate (OMP) from orotate (EC 2.4.2.10, orotate phosphoribosyltransferase) and the decarboxylation of OMP to form UMP (EC 4.1.1.23, OMP decarboxylase).
Publications: 1 Organism: Homo Sapiens
Pathways:Nucleotide Biosynthesis
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