| + |
1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate(3-) | up-regulates quantity 
precursor of
|
phosphatidylglycerol(1-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267027 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21641550 |
PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. We further demonstrate that PTPMT1 specifically dephosphorylates PGP in vitro. Loss of PTPMT1 leads to dramatic diminution of cardiolipin, which can be partially reversed by the expression of catalytic active PTPMT1. Our study identifies PTPMT1 as the mammalian PGP phosphatase and points to its role as a regulator of cardiolipin biosynthesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PGS1 | up-regulates
chemical modification
|
1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267023 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29034233 |
After activation of PA by the CDP-DAG synthase TAMM41 (Kutik et al., 2008), the phosphatidylglycerol phosphate synthase (PGS1) catalyzes the committed step by converting CDP-DAG to phosphatidylglycerol phosphate (PGP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPMT1 | down-regulates quantity 
chemical modification
|
1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate(3-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267026 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21641550 |
PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. We further demonstrate that PTPMT1 specifically dephosphorylates PGP in vitro. Loss of PTPMT1 leads to dramatic diminution of cardiolipin, which can be partially reversed by the expression of catalytic active PTPMT1. Our study identifies PTPMT1 as the mammalian PGP phosphatase and points to its role as a regulator of cardiolipin biosynthesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate(3-)