Name	UBE2C
Full Name	Ubiquitin-conjugating enzyme E2 C
Synonyms	(E3-independent) E2 ubiquitin-conjugating enzyme C, 2.3.2.24, E2 ubiquitin-conjugating enzyme C, UbcH10, Ubiquitin carrier protein C, Ubiquitin-protein ligase C \| UBCH10, UBCH10
Primary ID	O00762
Links	- -
Type	protein
Relations	4
Pathways	Prostate Cancer
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.