| + |
CSNK2A1 | up-regulates 
phosphorylation
|
PDCD5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187106 |
Ser119 |
NRRKVMDsDEDDDY |
Homo sapiens |
|
| pmid |
sentence |
| 19616514 |
Programmed cell death 5 (pdcd5), a protein involved in cell death and down-regulated in different forms of human tumors. Pdcd5 is phosphorylated in vitro by both ck2alpha subunit and by the ck2 holoenzyme at a residue, s118, which is found phosphorylated in vivo. Transfection of the non-phosphorylatable mutant (s118a) impairs the pdcd5 acceleration of either doxorubimicin- or uv-induced apoptosis in u2os cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPEF1 | down-regulates quantity by destabilization 
dephosphorylation
|
PDCD5 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277008 |
Ser119 |
NRRKVMDsDEDDDY |
Homo sapiens |
|
| pmid |
sentence |
| 28051100 |
Here, we report that the serine/threonine phosphatase PPEF-1 interacts with and dephosphorylates PDCD5 at Ser 119, which leads to PDCD5 destabilization.|These results demonstrate that PPEF-1 reduces PDCD5 stability via PDCD5 dephosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PDCD5
- 
- 