Relation Results

Summary

Name PDCD5
Full Name Programmed cell death protein 5
Synonyms TF-1 cell apoptosis-related protein 19, Protein TFAR19 | TFAR19
Primary ID O14737
Links - -
Type protein
Relations 2
Function May function in the process of apoptosis.

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Type: Score: Layout: SPV 
0.3540.2PPEF1PDCD5CSNK2A1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PPEF1down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation PDCD5 0.354
Identifier Residue Sequence Organism Cell Line
SIGNOR-277008 Ser119 NRRKVMDsDEDDDY Homo sapiens
pmid sentence
Here, we report that the serine/threonine phosphatase PPEF-1 interacts with and dephosphorylates PDCD5 at Ser 119, which leads to PDCD5 destabilization.|These results demonstrate that PPEF-1 reduces PDCD5 stability via PDCD5 dephosphorylation.
Publications: 1 Organism: Homo Sapiens
+ CSNK2A1up-regulates img/direct-activation.png phosphorylation PDCD5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-187106 Ser119 NRRKVMDsDEDDDY Homo sapiens
pmid sentence
Programmed cell death 5 (pdcd5), a protein involved in cell death and down-regulated in different forms of human tumors. Pdcd5 is phosphorylated in vitro by both ck2alpha subunit and by the ck2 holoenzyme at a residue, s118, which is found phosphorylated in vivo. Transfection of the non-phosphorylatable mutant (s118a) impairs the pdcd5 acceleration of either doxorubimicin- or uv-induced apoptosis in u2os cells
Publications: 1 Organism: Homo Sapiens
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