+ |
CDK1 | up-regulates
phosphorylation
|
FANCG |
0.361 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-129061 |
Ser387 |
PRFSPPPsPPGPCMP |
Homo sapiens |
|
pmid |
sentence |
15367677 |
S387a mutant abolished fancg fusion protein phosphorylation by cdc2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FANCG | form complex
binding
|
D1-D2-G-X3 complex |
0.727 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263254 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
18212739 |
These results argue that FANCG has a role independent of the FA core complex, and we propose that phosphorylation of serine 7 is the signalling event required for forming a discrete complex comprising FANCD1/BRCA2-FANCD2-FANCG-XRCC3 (D1-D2-G-X3). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FANCG | form complex
binding
|
Fanconi anemia core complex |
0.922 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263243 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
17396147 |
This complex includes not only the five known FA proteins (FANC‐A, C, E, F, and G), but also four new polypeptides, which are named FAAPs for FANCA‐associated polypeptides. |Thus, eight of the nine components of the FA core complex are FA proteins (FANC‐A, B, C, E, F, G, L, and M). Furthermore, two of the newly discovered FA proteins have enzymatic activities: FANCL is a ubiquitin ligase essential for FANCD2 monoubiquitination in vivo |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FANCG | up-regulates quantity by stabilization
|
SPTAN1 |
0.374 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263275 |
|
|
Homo sapiens |
Lymphoblastoid Cell Line |
pmid |
sentence |
19102630 |
In FA cells, deficiencies in FA proteins lead to decreased stability of alphaRIISp |These results demonstrate that one of the FA proteins, FANCG, contains a motif that interacts directly with the SH3 domain of alphaIISp. We propose that this binding of FANCG to alphaIISp may be important for the stability of alphaIISp in cells and the role alphaIISp plays in the DNA repair process.| |
|
Publications: |
1 |
Organism: |
Homo Sapiens |