4.0
Summary
| Name |  BUD23
|
| Full Name | 18S rRNA (guanine-N(7))-methyltransferase |
| Synonyms | Bud site selection protein 23 homolog, Metastasis-related methyltransferase 1, Williams-Beuren syndrome chromosomal region 22 protein, rRNA methyltransferase and ribosome maturation factor | MERM1, WBSCR22 |
| Primary ID | O43709 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | BUD23 | form complex 
binding
|
BUD23-TRM112 methyltransferase complex | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |