Summary

Name ENSA
Full Name Alpha-endosulfine
Synonyms ARPP-19e
Primary ID O43768
Links - -
Type protein
Relations 2
Function Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation ENSA 0.724
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding PPP2R2D 0.76
Publications: 1 Organism: In Vitro