Relation Results

Summary

Name TRAK2
Full Name Trafficking kinesin-binding protein 2
Synonyms Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein | ALS2CR3, KIAA0549
Primary ID O60296
Links - -
Type protein
Relations 1
Function May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

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Type: Score: Layout: SPV 
0.552KIF5CTRAK2

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Relations
Regulator
Mechanism
target
score ℹ
+ KIF5Cup-regulates activity img/direct-activation.png binding TRAK2 0.552
Identifier Residue Sequence Organism Cell Line
SIGNOR-264064 Homo sapiens HEK-293 Cell
pmid sentence
Trafficking kinesin proteins (TRAKs) are kinesin adaptors. They bind the cargo binding domain of kinesin-1 motor proteins forming a link between the motor and their cargoes. This supports the idea that the KIF5A–TRAK2 interaction is multivalent and could act to ensure stable motor-cargo interaction during intracellular trafficking; dimerization of both motor and adaptor molecules further enhances this stability (Fig. 6). A similar multivalent profile was found for the TRAK2 binding site within the kinesin-1 isoform, KIF5C.
Publications: 1 Organism: Homo Sapiens
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