Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264064 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
24161670 |
Trafficking kinesin proteins (TRAKs) are kinesin adaptors. They bind the cargo binding domain of kinesin-1 motor proteins forming a link between the motor and their cargoes. This supports the idea that the KIF5A–TRAK2 interaction is multivalent and could act to ensure stable motor-cargo interaction during intracellular trafficking; dimerization of both motor and adaptor molecules further enhances this stability (Fig. 6). A similar multivalent profile was found for the TRAK2 binding site within the kinesin-1 isoform, KIF5C. |
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