| Name
|
 ATP10A
|
| Full Name |
Phospholipid-transporting ATPase VA |
| Synonyms |
ATPase class V type 10A, Aminophospholipid translocase VA, P4-ATPase flippase complex alpha subunit ATP10A | ATP10C, ATPVA, ATPVC, KIAA0566 |
| Primary ID |
O60312 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
0 |
| Function |
Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane (PubMed:25947375, PubMed:29599178, PubMed:30530492). Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking (PubMed:29599178). Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix (PubMed:29599178, PubMed:25947375). Has low flippase activity toward glucosylceramide (GlcCer) (PubMed:30530492). |
4.0