Summary

Name ACSL4
Full Name Long-chain-fatty-acid--CoA ligase 4
Synonyms Long-chain acyl-CoA synthetase 4, LACS 4 | ACS4, FACL4, LACS4
Primary ID O60488
Links - -
Type protein
Relations 0
Function Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590).

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