3.0
Summary
| Name |  CBFA2T3
|
| Full Name | Protein CBFA2T3 |
| Synonyms | MTG8-related protein 2, Myeloid translocation gene on chromosome 16 protein, hMTG16, Zinc finger MYND domain-containing protein 4 | MTG16, MTGR2, ZMYND4 |
| Primary ID | O75081 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665). |
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