3.0
Summary
| Name |  NDUFS2View Modifications |
| Full Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial |
| Synonyms | Complex I-49kD, CI-49kD, NADH-ubiquinone oxidoreductase 49 kDa subunit | |
| Primary ID | O75306 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30922174, PubMed:22036843). Essential for the catalytic activity of complex I (PubMed:30922174, PubMed:22036843). Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK1 | up-regulates activity 
phosphorylation
|
NDUFS2 | 0.2 |
| Publications: | 1 | |||
| + | CyclinB/CDK1 | up-regulates activity
phosphorylation
|
NDUFS2 | 0.2 |
| Publications: | 1 | |||
| + | NDUFS2 | form complex 
binding
|
Mitochondrial respiratory chain complex I | 0.858 |
| Publications: | 1 | |||