Summary

Name EED
Full Name Polycomb protein EED
Synonyms hEED, WD protein associating with integrin cytoplasmic tails 1, WAIT-1
Primary ID O75530
Links - -
Type protein
Relations 2
Function Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding PRC2 0.08
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding SUZ12/EED 0.08
Publications: 1 Organism: Homo Sapiens