Summary

Name DGAT1
Full Name Diacylglycerol O-acyltransferase 1
Synonyms ACAT-related gene product 1, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, 2.3.1.76, Diglyceride acyltransferase | AGRP1, DGAT
Primary ID O75907
Links - -
Type protein
Relations 1
Inhibitors 959122-11-3
Function Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png chemical inhibition DGAT1
Publications: 1 Organism: Homo Sapiens