Summary

Name PLEKHG5
Full Name Pleckstrin homology domain-containing family G member 5
Synonyms PH domain-containing family G member 5, Guanine nucleotide exchange factor 720, GEF720 | KIAA0720
Primary ID O94827
Links - -
Type protein
Relations 1
Function Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631).

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Relations

Regulator Mechanism target score ℹ
+ PLEKHG5up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.759
Publications: 1 Organism: Homo Sapiens