Relation Results

Summary

Name KDM4B
Full Name Lysine-specific demethylase 4B
Synonyms JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B | JHDM3B, JMJD2B, KIAA0876
Primary ID O94953
Links - -
Type protein
Relations 19
Function Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys ...
View More

Viewer

Type: Score: Layout: SPV 
0.20.20.80.70.20.2840.20.20.20.3340.20.5960.2640.20.7KDM4BH3C1MAPK12-oxoglutarate(2-)DNA_damageHistone H3TP53BBC3EPAS1BBC3ARCDKN1AESR1HIF1ATP53I3Hypoxia

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ KDM4Bdown-regulates activity img/direct_inhibition.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263734 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
The KDM4 family of Jumonj domain histone demethylases specifically target di- and tri-methylated lysine 9 on histone H3 (H3K9me3), removing a modification central to defining heterochromatin and gene repression. The majority of studies regarding its function describe it as an activator that removes repressive H3K9me3 and H3K9me2 at or near regulated promoters in order to facilitate expression of the indicated pathways.
Publications: 1 Organism: Homo Sapiens
+ MAPK1up-regulates quantity by stabilization img/direct-activation.png phosphorylation KDM4B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276743 Ser352 TRPTALTsPELSSWS Homo sapiens HCT-116 Cell
pmid sentence
In addition, the phosphorylation of JMJD2B via p-ERK at Thr305, Ser352, Ser566 and Thr1065 contribute to JMJD2B stability. p-ERK stabilizes the JMJD2B protein level by protecting JMJD2B from ubiquitination and proteasome degradation. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-276742 Ser566 PTWKEPVsPMELTGP Homo sapiens HCT-116 Cell
pmid sentence
In addition, the phosphorylation of JMJD2B via p-ERK at Thr305, Ser352, Ser566 and Thr1065 contribute to JMJD2B stability. p-ERK stabilizes the JMJD2B protein level by protecting JMJD2B from ubiquitination and proteasome degradation. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-276744 Thr1065 AKRPRVGtPLATEDS Homo sapiens HCT-116 Cell
pmid sentence
In addition, the phosphorylation of JMJD2B via p-ERK at Thr305, Ser352, Ser566 and Thr1065 contribute to JMJD2B stability. p-ERK stabilizes the JMJD2B protein level by protecting JMJD2B from ubiquitination and proteasome degradation. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-276741 Thr305 IDYGKVAtQCTCRKD Homo sapiens HCT-116 Cell
pmid sentence
In addition, the phosphorylation of JMJD2B via p-ERK at Thr305, Ser352, Ser566 and Thr1065 contribute to JMJD2B stability. p-ERK stabilizes the JMJD2B protein level by protecting JMJD2B from ubiquitination and proteasome degradation. 
Publications: 4 Organism: Homo Sapiens
+ 2-oxoglutarate(2-)up-regulates activity img/direct-activation.png chemical activation KDM4B 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-273466
pmid sentence
Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. |2-OG is a central intermediate of the Krebs cycle, where it is produced by isocitrate dehydrogenase (IDH) isoenzymes 2 and 3.
Publications: 1
+ DNA_damageup-regulates img/indirect-activation.png KDM4B 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263736 Homo sapiens
pmid sentence
The KDM4 family of Jumonj domain histone demethylases specifically target di- and tri-methylated lysine 9 on histone H3 (H3K9me3), removing a modification central to defining heterochromatin and gene repression. KDM4 enzymes are generally over-expressed in cancers, making them compelling targets for study and therapeutic inhibition. One of these family members, KDM4B, is especially interesting due to its regulation by multiple cellular stimuli, including DNA damage, steroid hormones, and hypoxia.
Publications: 1 Organism: Homo Sapiens
+ KDM4Bdown-regulates activity img/direct_inhibition.png demethylation Histone H3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265359 Homo sapiens
pmid sentence
The KDM4 family of Jumonj domain histone demethylases specifically target di- and tri-methylated lysine 9 on histone H3 (H3K9me3), removing a modification central to defining heterochromatin and gene repression. The majority of studies regarding its function describe it as an activator that removes repressive H3K9me3 and H3K9me2 at or near regulated promoters in order to facilitate expression of the indicated pathways.
Publications: 1 Organism: Homo Sapiens
+ TP53up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM4B 0.284
Identifier Residue Sequence Organism Cell Line
SIGNOR-263729 Homo sapiens HCT-116 Cell
pmid sentence
KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. p53 directly regulates JMJD2B gene expression by binding to a canonical p53-consensus motif in the JMJD2B promoter.
Publications: 1 Organism: Homo Sapiens
+ KDM4Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BBC3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263732 Homo sapiens HCT-116 Cell
pmid sentence
JMJD2B induction attenuates the transcription of key p53 transcriptional targets including p21, PIG3 and PUMA, and this modulation is dependent on the catalytic capacity of JMJD2B.
Publications: 1 Organism: Homo Sapiens
+ EPAS1up-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM4B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271584 Homo sapiens
pmid sentence
To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C, KDM6B, and KDM7A) or repressed (KDM NO66 and KDM1A) by both HIF-1a and HIF-2a.
Publications: 1 Organism: Homo Sapiens
+ KDM4Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BBC3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263733 Homo sapiens HCT-116 Cell
pmid sentence
JMJD2B induction attenuates the transcription of key p53 transcriptional targets including p21, PIG3 and PUMA, and this modulation is dependent on the catalytic capacity of JMJD2B.
Publications: 1 Organism: Homo Sapiens
+ KDM4Bup-regulates quantity by expression img/indirect-activation.png transcriptional regulation AR 0.334
Identifier Residue Sequence Organism Cell Line
SIGNOR-254541 Homo sapiens
pmid sentence
KDM4B enzymatic activity is required to enhance AR transcriptional activity
Publications: 1 Organism: Homo Sapiens
+ KDM4Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDKN1A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263730 Homo sapiens HCT-116 Cell
pmid sentence
JMJD2B induction attenuates the transcription of key p53 transcriptional targets including p21, PIG3 and PUMA, and this modulation is dependent on the catalytic capacity of JMJD2B.
Publications: 1 Organism: Homo Sapiens
+ ESR1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KDM4B 0.596
Identifier Residue Sequence Organism Cell Line
SIGNOR-263737 Homo sapiens T-47D Cell
pmid sentence
Here, we show the histone demethylase JMJD2B is regulated by both ERalpha and HIF-1alpha, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as CCND1, CCNA1, and WEE1. these data indicate that JMJD2B is a bona fide target of ERα and its expression in ER-positive breast cancer cells is mainly dependent on ERα.
Publications: 1 Organism: Homo Sapiens
+ HIF1Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation KDM4B 0.264
Identifier Residue Sequence Organism Cell Line
SIGNOR-263738 Homo sapiens T-47D Cell
pmid sentence
Here, we show the histone demethylase JMJD2B is regulated by both ERalpha and HIF-1alpha, drives breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as CCND1, CCNA1, and WEE1.
Publications: 1 Organism: Homo Sapiens
+ HIF1Aup-regulates quantity by expression img/direct-activation.png transcriptional regulation KDM4B 0.264
Identifier Residue Sequence Organism Cell Line
SIGNOR-271569 Homo sapiens
pmid sentence
To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C, KDM6B, and KDM7A) or repressed (KDM NO66 and KDM1A) by both HIF-1a and HIF-2a.
Publications: 1 Organism: Homo Sapiens
+ KDM4Bdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TP53I3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263731 Homo sapiens HCT-116 Cell
pmid sentence
JMJD2B induction attenuates the transcription of key p53 transcriptional targets including p21, PIG3 and PUMA, and this modulation is dependent on the catalytic capacity of JMJD2B.
Publications: 1 Organism: Homo Sapiens
+ Hypoxiaup-regulates img/indirect-activation.png KDM4B 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263735 Homo sapiens
pmid sentence
The KDM4 family of Jumonj domain histone demethylases specifically target di- and tri-methylated lysine 9 on histone H3 (H3K9me3), removing a modification central to defining heterochromatin and gene repression. KDM4 enzymes are generally over-expressed in cancers, making them compelling targets for study and therapeutic inhibition. One of these family members, KDM4B, is especially interesting due to its regulation by multiple cellular stimuli, including DNA damage, steroid hormones, and hypoxia.
Publications: 1 Organism: Homo Sapiens
a simple tooltip