Summary

Name PLAT
Full Name Tissue-type plasminogen activator
Synonyms t-PA, t-plasminogen activator, tPA |
Primary ID P00750
Links - -
Type protein
Relations 5
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage PLAT 0.55
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ up-regulates activity img/direct-activation.png binding PLG 0.55
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ up-regulates img/indirect-activation.png PLAT 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PLAT 0.269
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLAT 0.2
Publications: 1 Organism: Homo Sapiens