Relation Results

Summary

Name PLAT
Full Name Tissue-type plasminogen activator
Synonyms t-PA, t-plasminogen activator, tPA |
Primary ID P00750
Links - -
Type protein
Relations 5
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediat ...
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Type: Score: Layout: SPV 
0.5710.2650.20.5710.2PLGPLATCREB1ATF2Fibrin

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PLGup-regulates activity img/direct-activation.png cleavage PLAT 0.571
Identifier Residue Sequence Organism Cell Line
SIGNOR-263534 Arg310 QYSQPQFrIKGGLFA Homo sapiens
pmid sentence
The conversion of plasminogen to plasmin can occur by several different mechanisms, but it appears that the most important in uiuo activator is tPA (2). tPA, M, = 70,000, is present in plasma as a single-chain serine protease, but proteolytic cleavage of the Agr275-Ile276 bond in tPA by plasmin yields a disulfide-linked two-chain enzyme
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ CREB1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PLAT 0.265
Identifier Residue Sequence Organism Cell Line
SIGNOR-253732 Homo sapiens HT-1080 Cell
pmid sentence
We suggest that the mechanism for the transcriptional down-regulation of t-PA by PMA in HT-1080 cells requires CREB-1 binding to the t-PACRE while ATF-2, by associating with the same site, plays a role in PMA-mediated induction of t-PA in HeLa cells.
Publications: 1 Organism: Homo Sapiens
+ ATF2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PLAT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253724 Homo sapiens HeLa Cell
pmid sentence
We suggest that the mechanism for the transcriptional down-regulation of t-PA by PMA in HT-1080 cells requires CREB-1 binding to the t-PACRE while ATF-2, by associating with the same site, plays a role in PMA-mediated induction of t-PA in HeLa cells.
Publications: 1 Organism: Homo Sapiens
+ PLATup-regulates activity img/direct-activation.png binding PLG 0.571
Identifier Residue Sequence Organism Cell Line
SIGNOR-263533 Homo sapiens
pmid sentence
The conversion of plasminogen to plasmin can occur by several different mechanisms, but it appears that the most important in uiuo activator is tPA (2). tPA, M, = 70,000, is present in plasma as a single-chain serine protease, but proteolytic cleavage of the Agr275-Ile276 bond in tPA by plasmin yields a disulfide-linked two-chain enzyme
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
+ Fibrinup-regulates img/indirect-activation.png PLAT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263536 Homo sapiens
pmid sentence
The presence of fibrin greatly accelerates the activation of plasminogen by tPA and hence can exert a regulatory influence over plasminogen activation
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Plasma
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