3.0
Summary
| Name |  PLATView Modifications |
| Full Name | Tissue-type plasminogen activator |
| Synonyms | t-PA, t-plasminogen activator, tPA | |
| Primary ID | P00750 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLG | up-regulates activity 
cleavage
|
PLAT | 0.555 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Blood Plasma | |||
| + | ATF2 | up-regulates quantity by expression 
transcriptional regulation
|
PLAT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Fibrin | up-regulates
|
PLAT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Blood Plasma | |||
| + | CREB1 | down-regulates quantity by repression 
transcriptional regulation
|
PLAT | 0.268 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLAT | up-regulates activity
binding
|
PLG | 0.555 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Blood Plasma | |||