Summary

Name PDGFB
Full Name Platelet-derived growth factor subunit B
Synonyms PDGF subunit B, PDGF-2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis | PDGF2, SIS
Primary ID P01127
Links - -
Type protein
Relations 2
Pathways Rhabdomyosarcoma
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PDGFRB 0.75
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PDGFRA 0.51
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma