Relation Results

Summary

Name OXT
Full Name Oxytocin-neurophysin 1
Synonyms OT-NPI | OT
Primary ID P01178
Links - -
Type protein
Relations 32
Pathways Oxytocin signaling
Function Neurophysin 1 specifically binds oxytocin.; FUNCTION

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0.20.20.20.20.20.20.20.2670.20.20.2540.20.20.5880.20.20.20.20.20.20.480.20.20.20.4310.20.369RARBOXTGABA-A (a1-b1-g2) receptorPAMCPEGABA-A (a3-b1-g2) receptorGABA-APCSK2GABA-A (a4-b3-d) receptorOXTRRARAPCSK5THRATAC1GABA-A (a5-b1-g2) receptorGABA-A (a6-b2-d) receptorGABA-A (a6-b3-d) receptorGABA-A (a2-b1-g2) receptorGABA-A (a4-b1-g2) receptorGABA-A (a6-b1-g2) receptorESR2CAPRIN2CREB3L1LNPEPESR1GABA-A (a4-b2-d) receptorCD38

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Relations
Regulator
Mechanism
target
score ℹ
+ RARBup-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268549 Homo sapiens
pmid sentence
The human and rat OT promoters could be stimulated by the ligand-activated estrogen receptors ERalpha and ERbeta, the thyroid hormone receptor THRapha, and the retinoic acid receptors RARalpha and RARbeta in a variety of cells (3, 477, 478). However, it is important to note that these results were obtained from cotransfection experiments in cell lines, i.e., under nonphysiological circumstances.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a1-b1-g2) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268579 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ Neurophysin 1up-regulates quantity img/direct-activation.png binding Oxytocin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270351 Homo sapiens Pituitary Gland Cell Line
pmid sentence
 Neurophysins I and II (NPI and NPII) serve in the neurosecretory granules of the posterior pituitary as carrier proteins for the neurophyseal hormones oxytocin (OT) and vasopressin (VP), respectively, until the latter are released into blood. 
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ PAMup-regulates activity img/direct-activation.png cleavage Oxytocin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268551 Homo sapiens
pmid sentence
Nevertheless, overall the results of this study show that peptide sequence recognition is an important aspect of the interactions of the prohormone substrates prooxytocin (3d) and procalcitonin (7e) with PAM, which is mirrored in the potency of analogous peptidomimetic glycolate inhibitors of the enzyme.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ CPEup-regulates activity img/direct-activation.png cleavage Oxytocin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270338 Homo sapiens
pmid sentence
First, OT preprohormone is produced, that will be cleaved and matured by successive enzymes. The OT gene encodes for the Pre-Pro-OT-Neurophysin I (pre-pro-hormone), which is cleaved by different enzymes to give rise to different OT intermediate forms and to the Neurophysin I, and finally to the mature amidated form that is released (Figure ​2).
Publications: 1 Organism: Homo Sapiens
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a3-b1-g2) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268581 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ Oxytocinup-regulates img/indirect-activation.png GABA-A 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268578 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ PCSK2up-regulates quantity img/direct-activation.png cleavage Neurophysin 1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270337 Homo sapiens Hypophysis
pmid sentence
Oxytocin-extended form is further cleaved by enzymatic activity to yield the nine-amino-acid active peptide, OT. The proteolysis may involve several pro-hormone convertases, convertase 2 (PC2) (20p11-1-11.2) and convertase 5 (PC5) (9q21.3) (Gabreels et al 1998). Both enzymes are found in OT neurosecretory vesicles and are a part of a family of subtilisen/kexinlike convertases (Seidah et al 1994). It is a product of the OT gene located at human gene locus 20p13 (Rao et al 1992). The processing cascade results in the production of neurophysin I and OT extended form (OT-X), which is OT with a C-terminal, three-amino-acid extension.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a4-b3-d) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268584 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ Oxytocinup-regulates activity img/direct-activation.png binding OXTR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268545 Homo sapiens
pmid sentence
The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in all vertebrates at several levels. The major site of OT gene expression is the magnocellular neurons of the hypothalamic paraventricular and supraoptic nuclei. In response to a variety of stimuli such as suckling, parturition, or certain kinds of stress, the processed OT peptide is released from the posterior pituitary into the systemic circulation.| The OT receptor is a typical class I G protein-coupled receptor that is primarily coupled via G(q) proteins to phospholipase C-beta.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ RARAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.254
Identifier Residue Sequence Organism Cell Line
SIGNOR-268548 Homo sapiens
pmid sentence
The human and rat OT promoters could be stimulated by the ligand-activated estrogen receptors ERalpha and ERbeta, the thyroid hormone receptor THRapha, and the retinoic acid receptors RARalpha and RARbeta in a variety of cells (3, 477, 478). However, it is important to note that these results were obtained from cotransfection experiments in cell lines, i.e., under nonphysiological circumstances.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ PCSK5up-regulates quantity img/direct-activation.png cleavage Oxytocin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270334 Homo sapiens Hypophysis
pmid sentence
Oxytocin-extended form is further cleaved by enzymatic activity to yield the nine-amino-acid active peptide, OT. The proteolysis may involve several pro-hormone convertases, convertase 2 (PC2) (20p11-1-11.2) and convertase 5 (PC5) (9q21.3) (Gabreels et al 1998). Both enzymes are found in OT neurosecretory vesicles and are a part of a family of subtilisen/kexinlike convertases (Seidah et al 1994). It is a product of the OT gene located at human gene locus 20p13 (Rao et al 1992). The processing cascade results in the production of neurophysin I and OT extended form (OT-X), which is OT with a C-terminal, three-amino-acid extension.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ THRAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268550 Homo sapiens
pmid sentence
The human and rat OT promoters could be stimulated by the ligand-activated estrogen receptors ERalpha and ERbeta, the thyroid hormone receptor THRapha, and the retinoic acid receptors RARalpha and RARbeta in a variety of cells (3, 477, 478). However, it is important to note that these results were obtained from cotransfection experiments in cell lines, i.e., under nonphysiological circumstances.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ TAC1up-regulates quantity img/indirect-activation.png OXT 0.588
Identifier Residue Sequence Organism Cell Line
SIGNOR-268576
pmid sentence
Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions|Functionally, activation of PVH-projecting Tac1+ neurons increases firing of oxytocin neurons, promotes social interactions, and increases preference for the social touch context, whereas reducing activity of Tac1+ neurons abolishes ST-induced oxytocin neuronal firing.
Publications: 1
Pathways:Oxytocin signaling
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a5-b1-g2) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268585 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a6-b2-d) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268587 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ Oxytocinup-regulates img/direct-activation.png binding OXTR 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-16758 Homo sapiens
pmid sentence
The oxytocin receptor, expressed in xenopus oocytes, specifically responds to oxytocin and induces an inward membrane current
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a6-b3-d) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268588 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a2-b1-g2) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268580 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ PCSK5down-regulates quantity img/direct_inhibition.png cleavage OXT 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-270327 Homo sapiens Hypophysis
pmid sentence
Oxytocin-extended form is further cleaved by enzymatic activity to yield the nine-amino-acid active peptide, OT. The proteolysis may involve several pro-hormone convertases, convertase 2 (PC2) (20p11-1-11.2) and convertase 5 (PC5) (9q21.3) (Gabreels et al 1998). Both enzymes are found in OT neurosecretory vesicles and are a part of a family of subtilisen/kexinlike convertases (Seidah et al 1994). It is a product of the OT gene located at human gene locus 20p13 (Rao et al 1992). The processing cascade results in the production of neurophysin I and OT extended form (OT-X), which is OT with a C-terminal, three-amino-acid extension.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a4-b1-g2) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268582 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a6-b1-g2) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268586 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ PCSK5up-regulates quantity img/direct-activation.png cleavage Neurophysin 1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270336 Homo sapiens Hypophysis
pmid sentence
Oxytocin-extended form is further cleaved by enzymatic activity to yield the nine-amino-acid active peptide, OT. The proteolysis may involve several pro-hormone convertases, convertase 2 (PC2) (20p11-1-11.2) and convertase 5 (PC5) (9q21.3) (Gabreels et al 1998). Both enzymes are found in OT neurosecretory vesicles and are a part of a family of subtilisen/kexinlike convertases (Seidah et al 1994). It is a product of the OT gene located at human gene locus 20p13 (Rao et al 1992). The processing cascade results in the production of neurophysin I and OT extended form (OT-X), which is OT with a C-terminal, three-amino-acid extension.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ PCSK2up-regulates quantity img/direct-activation.png cleavage Oxytocin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270335 Homo sapiens Hypophysis
pmid sentence
Oxytocin-extended form is further cleaved by enzymatic activity to yield the nine-amino-acid active peptide, OT. The proteolysis may involve several pro-hormone convertases, convertase 2 (PC2) (20p11-1-11.2) and convertase 5 (PC5) (9q21.3) (Gabreels et al 1998). Both enzymes are found in OT neurosecretory vesicles and are a part of a family of subtilisen/kexinlike convertases (Seidah et al 1994). It is a product of the OT gene located at human gene locus 20p13 (Rao et al 1992). The processing cascade results in the production of neurophysin I and OT extended form (OT-X), which is OT with a C-terminal, three-amino-acid extension.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ PCSK2down-regulates quantity img/direct_inhibition.png cleavage OXT 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-270328 Homo sapiens Hypophysis
pmid sentence
Oxytocin-extended form is further cleaved by enzymatic activity to yield the nine-amino-acid active peptide, OT. The proteolysis may involve several pro-hormone convertases, convertase 2 (PC2) (20p11-1-11.2) and convertase 5 (PC5) (9q21.3) (Gabreels et al 1998). Both enzymes are found in OT neurosecretory vesicles and are a part of a family of subtilisen/kexinlike convertases (Seidah et al 1994). It is a product of the OT gene located at human gene locus 20p13 (Rao et al 1992). The processing cascade results in the production of neurophysin I and OT extended form (OT-X), which is OT with a C-terminal, three-amino-acid extension.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ ESR2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.48
Identifier Residue Sequence Organism Cell Line
SIGNOR-268547 Homo sapiens
pmid sentence
The human and rat OT promoters could be stimulated by the ligand-activated estrogen receptors ERalpha and ERbeta, the thyroid hormone receptor THRapha, and the retinoic acid receptors RARalpha and RARbeta in a variety of cells (3, 477, 478). However, it is important to note that these results were obtained from cotransfection experiments in cell lines, i.e., under nonphysiological circumstances.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ CAPRIN2up-regulates quantity by stabilization img/direct-activation.png post transcriptional regulation OXT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268556 Homo sapiens HEK-293 Cell
pmid sentence
Transcriptional and post-transcriptional regulation of oxytocin and vasopressin gene expression by CREB3L1 and CAPRIN2|Altogether, the data indicate that CAPRIN2 binds Oxt mRNA |Therefore, we propose that CAPRIN2 facilitates post-transcriptional modifications that increase Oxt transcript stability.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ CREB3L1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268555 Homo sapiens HEK-293 Cell
pmid sentence
Transcriptional and post-transcriptional regulation of oxytocin and vasopressin gene expression by CREB3L1 and CAPRIN2|By luciferase assays, we demonstrate that CREB3L1 may be a transcription factor regulating Oxt gene expression. By RNA immunoprecipitation assays and northern blot analysis of Oxt mRNA poly(A) tails, we have found that CAPRIN2 binds Oxt mRNA and regulates its poly(A) tail length.|To investigate transcriptional regulation of the OXT gene by CREB3L1, we performed luciferase assays using a proximal Oxt promoter region transfected in HEK293T cells. The expression of full-length CREB3L1 (CREB3L1FL) and a constitutively active CREB3L1 (CREB3L1CA) significantly increased luciferase activity by 5.4- and 3.2-fold, respectively, compared with controls
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ LNPEPdown-regulates quantity by destabilization img/direct_inhibition.png cleavage Oxytocin 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268552 Homo sapiens
pmid sentence
It has been shown that the steady state of the mature OT form can be controlled by an oxytocinase (P-LAP) that is produced in periphery and centrally by the OT-magnocellular neurons. Noticeably, P-LAP is also expressed in parvocellular OT neurons and in other brain structures| The OT intermediate forms are produced from E16.5 (see above) but the mature amidated OT form is detected only from birth. The released mature form is then degraded by an oxytocinase (PLAP)
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ ESR1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.431
Identifier Residue Sequence Organism Cell Line
SIGNOR-268546 Homo sapiens
pmid sentence
The human and rat OT promoters could be stimulated by the ligand-activated estrogen receptors ERalpha and ERbeta, the thyroid hormone receptor THRapha, and the retinoic acid receptors RARalpha and RARbeta in a variety of cells (3, 477, 478). However, it is important to note that these results were obtained from cotransfection experiments in cell lines, i.e., under nonphysiological circumstances.
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ Oxytocinup-regulates img/indirect-activation.png GABA-A (a4-b2-d) receptor 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268583 Homo sapiens
pmid sentence
OT inhibits corticotropin-releasing factor (CRF) mRNA expression at the hypothalamus, resulting in antistress and anti-anxiety effects| It has been demonstrated that the inhibitory effect of OT on CRF mRNA expression is not a direct one on CRF neurons. GABAergic neurons are present in the surroundings of the PVN (peri-PVN). These GABA-projecting neurons into the PVN inhibits CRF expression via GABAA receptors
Publications: 1 Organism: Homo Sapiens
+ CD38up-regulates quantity img/indirect-activation.png relocalization OXT 0.369
Identifier Residue Sequence Organism Cell Line
SIGNOR-268544 Mus musculus
pmid sentence
CD38 is critical for social behaviour by regulating oxytocin secretion|Consistently, the plasma level of oxytocin (OT), but not vasopressin, was strongly decreased in CD38-/- mice. Replacement of OT by subcutaneous injection or lentiviral-vector-mediated delivery of human CD38 in the hypothalamus rescued social memory and maternal care in CD38-/- mice.
Publications: 1 Organism: Mus Musculus
Pathways:Oxytocin signaling
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