Relation Results

Summary

Name ITGB1
Full Name Integrin beta-1
Synonyms Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta | FNRB, MDF2, MSK12
Primary ID P05556
Links - -
Type protein
Relations 48
Pathways Integrin Signaling
Function Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 ...
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Type: Score: Layout: SPV 
0.5120.2670.9130.7910.2950.7510.20.7530.7990.6970.7660.20.20.20.20.20.3940.20.8310.7750.8040.6810.20.20.7010.20.7510.20.8140.20.20.20.20.20.20.8150.20.3190.20.2820.20.20.20.20.2PTP4A3ITGB1PTPRGA5/b1 integrinTLN1TWIST1A2/b1 integrinPCDHA13ITGB1BP1A3/b1 integrinA11/b1 integrina7/b1 integrinHOXD1PCDHA1PCDHA8PCDHA5PCDHAC2FERMT3KindlinAv/b1 integrinA9/b1 integrinA4/b1 integrinA10/b1 integrinPCDHA10PCDHA6PTK2PCDH10A1/b1 integrinPCDHA12A8/b1 integrinPCDH9NEXMIFPCDHA9PCDHAC1KCNH2A6/b1 integrinPCDHA4DOK1PCDHA3TWIST2Protocadherin_betaPCDHA11PCDHA2PRKCQPCDHA7

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PTP4A3down-regulates activity img/direct_inhibition.png dephosphorylation ITGB1 0.512
Identifier Residue Sequence Organism Cell Line
SIGNOR-277050 Tyr783 DTGENPIyKSAVTTV Homo sapiens
pmid sentence
In this study, we demonstrate that PRL-3 directly binds to integrin \u03b21 and dephosphorylates integrin \u03b21-Y783, a key residue for integrin \u03b21 function [ ].|These results indicate that PRL-3 dephosphorylates integrin \u03b21 in vitro and in vivo.
Publications: 1 Organism: Homo Sapiens
+ PTPRGdown-regulates activity img/direct_inhibition.png dephosphorylation ITGB1 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-254706 Tyr783 DTGENPIyKSAVTTV in vitro
pmid sentence
PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and VCL correlates with tyrosine dephosphorylation. In contrast, SRC inhibition correlates with hyperphosphorylation of the inhibitory Tyr530 residue and with dephosphorylation of the activatory Tyr419. Moreover, CDK2 and CTTN inhibition correlates with a hyperphosphorylation of the inhibitory Tyr15 and Tyr470, respectively. In contrast, a subgroup of 13 proteins, including BLNK, DOK2, ERBB2, GRIN2B, INSR, PDGFRA, PRKCD, PXN, STAT1, STAT2, STAT3, STAT5A, and ZAP70, appears to be activated by PTPRG activity.
Publications: 1 Organism: In Vitro
+ ITGB1form complex img/form-complex.png binding A5/b1 integrin 0.913
Identifier Residue Sequence Organism Cell Line
SIGNOR-253178
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ TLN1up-regulates activity img/direct-activation.png binding ITGB1 0.791
Identifier Residue Sequence Organism Cell Line
SIGNOR-257593 Mus musculus Blood Platelet
pmid sentence
Over the past 10 years, the binding of talin to the cytoplasmic tail of integrin-β subunits has been established to have a key role in integrin activation. Binding of the phosphotyrosinebinding (PTB)-domain-like subdomain of the protein 4.1, ezrin, radixin, moesin (FERM) domain of talin to the conserved WxxxNP(I/L)Y motif of the β-integrin tail permits additional weaker interactions between talin and the membrane-proximal region of the tail that trigger integrin activation, probably through the disruption of inhibitory interactions between α- and β-subunit cytoplasmic tails.
Identifier Residue Sequence Organism Cell Line
SIGNOR-257607 Mus musculus Blood Platelet
pmid sentence
Over the past 10 years, the binding of talin to the cytoplasmic tail of integrin-β subunits has been established to have a key role in integrin activation. Binding of the phosphotyrosinebinding (PTB)-domain-like subdomain of the protein 4.1, ezrin, radixin, moesin (FERM) domain of talin to the conserved WxxxNP(I/L)Y motif of the β-integrin tail permits additional weaker interactions between talin and the membrane-proximal region of the tail that trigger integrin activation, probably through the disruption of inhibitory interactions between α- and β-subunit cytoplasmic tails.
Publications: 2 Organism: Mus Musculus
Pathways:Integrin Signaling
+ TWIST1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.295
Identifier Residue Sequence Organism Cell Line
SIGNOR-255516 Homo sapiens HEY Cell
pmid sentence
Immunoblot analysis showed that HEY/si-TWIST cells exhibited decreased expression levels of CD29, CD44 and CD54 compared to those of HEY/si-scrambled cells
Publications: 1 Organism: Homo Sapiens
+ ITGB1form complex img/form-complex.png binding A2/b1 integrin 0.751
Identifier Residue Sequence Organism Cell Line
SIGNOR-253172
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ PCDHA13up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265672 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ ITGB1BP1down-regulates activity img/direct_inhibition.png binding ITGB1 0.753
Identifier Residue Sequence Organism Cell Line
SIGNOR-257638 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ ITGB1form complex img/form-complex.png binding A3/b1 integrin 0.799
Identifier Residue Sequence Organism Cell Line
SIGNOR-253174
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ ITGB1form complex img/form-complex.png binding A11/b1 integrin 0.697
Identifier Residue Sequence Organism Cell Line
SIGNOR-253188
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ ITGB1form complex img/form-complex.png binding a7/b1 integrin 0.766
Identifier Residue Sequence Organism Cell Line
SIGNOR-241512 Homo sapiens Myoblast, Skeletal Muscle Fiber
pmid sentence
The alpha7beta1 integrin is a laminin receptor on the surface of skeletal myoblasts and myofibers. Alternative forms of both the alpha7 and beta1 chains are expressed in a developmentally regulated fashion during myogenesis. These different alpha7beta1 isoforms localize at specific sites on myofibers and appear to have distinct functions in skeletal muscle.
Publications: 1 Organism: Homo Sapiens
+ HOXD1up-regulates quantity by expression img/direct-activation.png transcriptional regulation ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261648 Homo sapiens HUVEC Cell
pmid sentence
Consistently, ITGB1 promoter activity was decreased by HOXD1 knockdown in ECs. Furthermore, we identified the putative HOXD1-binding sites in the promoter region of ITGB1. Together, these findings suggest that HOXD1 plays a significant role in EC functions by regulating the expression of ITGB1.
Publications: 1 Organism: Homo Sapiens
+ PCDHA1up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265663 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ PCDHA8up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265671 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ PCDHA5up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265669 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ PCDHAC2up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269033 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269038 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 2 Organism: Homo Sapiens
Tissue: Central Nervous System
+ FERMT3up-regulates activity img/direct-activation.png binding ITGB1 0.394
Identifier Residue Sequence Organism Cell Line
SIGNOR-266065 Mus musculus Blood Platelet, RAW-264.7 Cell
pmid sentence
Mechanistically, Kindlin-3 can directly bind to regions of beta-integrin tails distinct from those of Talin and trigger integrin activation. We have therefore identified Kindlin-3 as a novel and essential element for platelet integrin activation in hemostasis and thrombosis|Kindlin-3 was also able to interact with the wild-type beta1 and beta3 integrin tails (Fig. 3c), in the presence and absence of Talin1 (Supplementary Fig. 3 online), and the F3 subdomain of Kindlin-3 was sufficient for this interaction and this interaction occurred in a direct manner
Publications: 1 Organism: Mus Musculus
+ Kindlinup-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-258999 Homo sapiens
pmid sentence
Kindlins bind with β-integrin cytoplasmic tails and execute broad biological functions including directed cell migration, proliferation, differentiation and survival.
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ ITGB1form complex img/form-complex.png binding Av/b1 integrin 0.831
Identifier Residue Sequence Organism Cell Line
SIGNOR-253202
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ ITGB1form complex img/form-complex.png binding A9/b1 integrin 0.775
Identifier Residue Sequence Organism Cell Line
SIGNOR-253184
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ ITGB1form complex img/form-complex.png binding A4/b1 integrin 0.804
Identifier Residue Sequence Organism Cell Line
SIGNOR-253176
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ ITGB1form complex img/form-complex.png binding A10/b1 integrin 0.681
Identifier Residue Sequence Organism Cell Line
SIGNOR-253186
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ PCDHA10up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265664 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ PCDHA6up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265666 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ ITGB1up-regulates activity img/indirect-activation.png PTK2 0.701
Identifier Residue Sequence Organism Cell Line
SIGNOR-257700 Homo sapiens
pmid sentence
Focal adhesion kinase (FAK) is activated by growth factors and integrins during migration, and functions as a receptor-proximal regulator of cell motility. At contacts between cells and the extracellular matrix, FAK functions as an adaptor protein to recruit other focal contact proteins or their regulators, which affects the assembly or disassembly of focal contacts. Whereas it was first hypothesized that FAK might bind directly to the cytoplasmic tails of integrins, accumulated evidence supports an indirect association of FAK with integrins through binding to integrin-associated proteins such as paxillin and talin.
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ PCDH10up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269034 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ ITGB1form complex img/form-complex.png binding A1/b1 integrin 0.751
Identifier Residue Sequence Organism Cell Line
SIGNOR-253170
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
Pathways:Integrin Signaling
+ PCDHA12up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265673 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ ITGB1form complex img/form-complex.png binding A8/b1 integrin 0.814
Identifier Residue Sequence Organism Cell Line
SIGNOR-253182
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
+ PCDH9up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269035 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ NEXMIFup-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269661 Rattus norvegicus Neuron
pmid sentence
Xpn regulates N-cadherin and β1-integrin expression at the transcriptional level in PC12 cells
Publications: 1 Organism: Rattus Norvegicus
+ PCDHA9up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265662 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
+ PCDHAC1up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269037 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269032 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 2 Organism: Homo Sapiens
Tissue: Central Nervous System
+ KCNH2up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277613 Homo sapiens
pmid sentence
One such mechanism is operant in colorectal cancer (CRC) cells. On integrin-dependent CRC cell adhesion, the Kv11.1/β1 integrin complex recruits the PI3K p85 subunit, which stimulates AKT phosphorylation and thus regulates autophagy
Publications: 1 Organism: Homo Sapiens
+ ITGB1up-regulates activity img/direct-activation.png binding KCNH2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277614 Homo sapiens
pmid sentence
One such mechanism is operant in colorectal cancer (CRC) cells. On integrin-dependent CRC cell adhesion, the Kv11.1/β1 integrin complex recruits the PI3K p85 subunit, which stimulates AKT phosphorylation and thus regulates autophagy
Publications: 1 Organism: Homo Sapiens
+ ITGB1form complex img/form-complex.png binding A6/b1 integrin 0.815
Identifier Residue Sequence Organism Cell Line
SIGNOR-253180
pmid sentence
Integrins are one of the major families of cell adhesion receptors (Humphries, 2000; Hynes, 2002). All integrins are non-covalently-linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and mostly short cytoplasmic domains (Springer and Wang, 2004; Arnaout et al., 2005). Mammalian genomes contain 18 α subunit and 8 β subunit genes, and to date 24 different α,β combinations have been identified at the protein level. Although some subunits only appear in a single heterodimer, twelve integrins contain the β1 subunit, and five contain αV.
Publications: 1
Pathways:Integrin Signaling
+ PCDHA4up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265665 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ DOK1down-regulates activity img/direct_inhibition.png binding ITGB1 0.319
Identifier Residue Sequence Organism Cell Line
SIGNOR-257669 Homo sapiens
pmid sentence
Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ PCDHA3up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265668 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ TWIST2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.282
Identifier Residue Sequence Organism Cell Line
SIGNOR-255513 Homo sapiens HEY Cell
pmid sentence
Immunoblot analysis showed that HEY/si-TWIST cells exhibited decreased expression levels of CD29, CD44 and CD54 compared to those of HEY/si-scrambled cells
Publications: 1 Organism: Homo Sapiens
+ Protocadherin_betaup-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269039 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ PCDHA11up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265670 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ PCDHA2up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265661 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ PRKCQup-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-241525 Mus musculus C2C12 Cell
pmid sentence
It is known that the teta isoform of the PKC family promotes the fusion of myoblasts and regulates the expression of caveolin-3 and beta1D integrin [15]. Of note, it has also been demonstrated that PKCepsilon expression increases during insulin-induced myogenic differentiation of the C2C12 cells.
Publications: 1 Organism: Mus Musculus
+ PCDHA7up-regulates activity img/direct-activation.png binding ITGB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265667 Homo sapiens
pmid sentence
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
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