4.0
Summary
| Name |  POLB
|
| Full Name | DNA polymerase beta |
| Synonyms | DPOLB_HUMAN | |
| Primary ID | P06746 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Inhibitors | clofarabine |
| Function | Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. |
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