Relation Results

Summary

Name GP1BA
Full Name Platelet glycoprotein Ib alpha chain
Synonyms GP-Ib alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha, Antigen CD42b-alpha |
Primary ID P07359
Links - -
Type protein
Relations 4
Function GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already b ...
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Type: Score: Layout: SPV 
0.2850.7070.3980.544ADAM17GP1BAGPIb-IX-V complexRUNX1GATA1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ ADAM17down-regulates activity img/direct_inhibition.png cleavage GP1BA 0.285
Identifier Residue Sequence Organism Cell Line
SIGNOR-261861 Val466 ATSPTILvSATSLIT Homo sapiens Blood Platelet
pmid sentence
GPIbα is shed by metalloproteases such as ADAM17, a process that releases a soluble GPIbα fragment termed glycocalicin. ADAM17 cleaves within the GPIbα-based peptide (LRGV465LK) through a mechanism that is only partially understood [42]. GPIbα shedding has been shown to be constitutive but it can be increased by activation of protein kinases C (PKC) or inhibition of calmodulin [42, 43]. Shedding leads to decreased receptor density
Publications: 1 Organism: Homo Sapiens
+ GP1BAform complex img/form-complex.png binding GPIb-IX-V complex 0.707
Identifier Residue Sequence Organism Cell Line
SIGNOR-261847 Homo sapiens Blood Platelet
pmid sentence
The GPIb-V-IX receptor consists of 4 transmembrane subunits: GPIbα, disulfide-linked to GPIbβ, and the noncovalently associated GPIX and GPV components, in ratios of 2:2:2:1.
Publications: 1 Organism: Homo Sapiens
+ RUNX1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP1BA 0.398
Identifier Residue Sequence Organism Cell Line
SIGNOR-254195 Homo sapiens
pmid sentence
We and others have previously shown that RUNX1 and GATA-1 physically interact and cooperate in the activation of megakaryocytic promoters such as alpha IIb integrin and glycoprotein Ibalpha.
Publications: 1 Organism: Homo Sapiens
+ GATA1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP1BA 0.544
Identifier Residue Sequence Organism Cell Line
SIGNOR-254191 Homo sapiens
pmid sentence
We and others have previously shown that RUNX1 and GATA-1 physically interact and cooperate in the activation of megakaryocytic promoters such as alpha IIb integrin and glycoprotein Ibalpha.
Publications: 1 Organism: Homo Sapiens
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