Summary

Name SNRPA
Full Name U1 small nuclear ribonucleoprotein A
Synonyms U1 snRNP A, U1-A, U1A |
Primary ID P09012
Links - -
Type protein
Relations 2
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding U1 snRNP complex 0.818
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding U4/U6.U5 snRNP complex 0.666
Publications: 1 Organism: Homo Sapiens