3.0
Summary
| Name |  H2AC11View Modifications |
| Full Name | Histone H2A type 1 |
| Synonyms | H2A.1, Histone H2A/p | H2AFP, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, H2AC13, H2AC15, H2AC16, H2AC17, H2AC13, H2AC15, H2AC16, H2AC17, H2AC13, H2AC15, H2AC16, H2AC17 |
| Primary ID | P0C0S8 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | DZIP3 | up-regulates activity 
monoubiquitination
|
H2AC11 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPS6KA5 | up-regulates
phosphorylation
|
H2AC11 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRPM6 | down-regulates activity 
phosphorylation
|
H2AC11 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | BUB1 |
phosphorylation
|
H2AC11 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF8 | up-regulates
ubiquitination
|
H2AC11 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SLBP | up-regulates quantity by expression
translation regulation
|
H2AC11 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | H2AC11 | up-regulates
binding
|
RNF168 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BRCC3 | down-regulates
deubiquitination
|
H2AC11 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | H2AC11 | up-regulates activity
relocalization
|
SGO1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |