Relation Results

Summary

Name H2AC11
Full Name Histone H2A type 1
Synonyms H2A.1, Histone H2A/p | H2AFP, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM, H2AC13, H2AC15, H2AC16, H2AC17, H2AC13, H2AC15, H2AC16, H2AC17, H2AC13, H2AC15, H2AC16, H2AC17
Primary ID P0C0S8
Links - -
Type protein
Relations 9
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DN ...
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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.20.2DZIP3H2AC11TRPM6RPS6KA5BUB1SGO1RNF8BRCC3SLBPRNF168

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ DZIP3up-regulates activity img/direct-activation.png monoubiquitination H2AC11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271749 Lys119 IQAVLLPkKTESHHK Homo sapiens HEK-293 Cell
pmid sentence
 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation. H2A monoubiquitination acts to prevent FACT recruitment at the transcriptional promoter region, blocking RNA polymerase II release at the early stage of elongation.
Publications: 1 Organism: Homo Sapiens
+ TRPM6down-regulates activity img/direct_inhibition.png phosphorylation H2AC11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276008 Ser2 sGRGKQGG in vitro
pmid sentence
We found that MSK1 phosphorylated histone H2A on serine 1, and mutation of serine 1 to alanine blocked the inhibition of transcription by MSK1. 
Publications: 1 Organism: In Vitro
+ RPS6KA5up-regulates img/direct-activation.png phosphorylation H2AC11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-123383 Ser2 sGRGKQGG Homo sapiens
pmid sentence
We found that msk1 phosphorylated histone h2a on serine 1, and mutation of serine 1 to alanine blocked the inhibition of transcription by msk1.
Publications: 1 Organism: Homo Sapiens
+ BUB1 img/unknown.png phosphorylation H2AC11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265261 Thr121 AVLLPKKtESHHKAK Homo sapiens
pmid sentence
the localization of hBub1 kinase usually defines the centromere-specific phosphorylation of H2A-T120. Accordingly, hSgo1 localized along the whole chromosome length in H2B-hBub1deltaN cells (Fig. 6D), indicating that H2A-pT120 plays a predominant role in defining shugoshin localization sites on the human chromosomes
Publications: 1 Organism: Homo Sapiens
+ H2AC11up-regulates activity img/direct-activation.png relocalization SGO1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265262 Homo sapiens HeLa Cell
pmid sentence
The complex between shugoshin and protein phosphatase 2A (Sgo1-PP2A) localizes to centromeres in mitosis, binds to cohesin in a reaction requiring Cdk-dependent phosphorylation of Sgo1, dephosphorylates cohesin-bound sororin, and protects a centromeric pool of cohesin from mitotic kinases and the cohesin inhibitor Wapl.|The centromeric localization of Sgo1 requires histone H2A phosphorylation at T120 (H2A-pT120) by the kinase Bub1.
Publications: 1 Organism: Homo Sapiens
+ RNF8up-regulates img/direct-activation.png ubiquitination H2AC11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-166174 Homo sapiens
pmid sentence
Rnf8 and ubc13 ubiquitylate h2a and h2ax, but other substrates probably exist.
Publications: 1 Organism: Homo Sapiens
+ BRCC3down-regulates img/direct_inhibition.png deubiquitination H2AC11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-167142 Homo sapiens
pmid sentence
Brcc36 regulates the abundance of lys(63)-linked ubiquitin chains at chromatin and that one of its substrates is diubiquitinated histone h2a
Publications: 1 Organism: Homo Sapiens
+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation H2AC11 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265403 Homo sapiens U2-OS Cell
pmid sentence
Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP participates in translation of the histone mRNA|We used radiolabeled probes generated by PCR targeting the open reading frame (ORF) to detect histones H2A, H2B, H3, H4, and H1 and used 7SK snRNA as a loading control (Fig. 2A). The abundance of histone H2A, H2B, H3, and H4 mRNAs is reduced to 37% to 70% of control levels in the SLBP knockdown cells when compared to the C2 control.
Publications: 1 Organism: Homo Sapiens
+ H2AC11up-regulates img/direct-activation.png binding RNF168 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-183890 Homo sapiens
pmid sentence
Rnf168 is recruited to sites of dna damage by binding to ubiquitylated histone h2a.
Publications: 1 Organism: Homo Sapiens
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