Relation Results

Summary

Name H2AB2
Full Name Histone H2A-Bbd type 2/3
Synonyms H2A Barr body-deficient, H2A.Bbd | H2AFB2
Primary ID P0C5Z0
Links - -
Type protein
Relations 1
Function Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosom ...
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Type: Score: Layout: SPV 
0.2SLBPH2AB2

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Relations
Regulator
Mechanism
target
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+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation H2AB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265407 Homo sapiens U2-OS Cell
pmid sentence
Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP participates in translation of the histone mRNA|We used radiolabeled probes generated by PCR targeting the open reading frame (ORF) to detect histones H2A, H2B, H3, H4, and H1 and used 7SK snRNA as a loading control (Fig. 2A). The abundance of histone H2A, H2B, H3, and H4 mRNAs is reduced to 37% to 70% of control levels in the SLBP knockdown cells when compared to the C2 control.
Publications: 1 Organism: Homo Sapiens
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