4.0
Summary
| Name |  CETP
|
| Full Name | Cholesteryl ester transfer protein |
| Synonyms | Lipid transfer protein I |
| Primary ID | P11597 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Inhibitors | Anacetrapib; 2-methylpropanethioic acid S-[2-[[[1-(2-ethylbutyl)cyclohexyl]-oxomethyl]amino]phenyl] ester |
| Function | Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641, PubMed:3281933). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | Anacetrapib | down-regulates 
chemical inhibition
|
CETP | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 2-methylpropanethioic acid S-[2-[[[1-(2-ethylbutyl)cyclohexyl]-oxomethyl]amino]phenyl] ester | down-regulates
chemical inhibition
|
CETP | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |