Summary

Name UBA1
Full Name Ubiquitin-like modifier-activating enzyme 1
Synonyms Protein A1S9, Ubiquitin-activating enzyme E1 | A1S9T, UBE1
Primary ID P22314
Links - -
Type protein
Relations 4
Pathways Ubiquitin activation
Function Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation UBA1 0.415
Publications: 3 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Ub:E1 (UBA1 substrate) 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation