4.0
Summary
| Name |  CALR
|
| Full Name | Calreticulin |
| Synonyms | CRP55, Calregulin, Endoplasmic reticulum resident protein 60, ERp60, HACBP, grp60 | CRTC |
| Primary ID | P27797 |
| Links |  -  -  |
| Type | protein |
| Relations | 0 |
| Function | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). |