Summary

Name PSMB9
Full Name Proteasome subunit beta type-9
Synonyms Low molecular mass protein 2, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, Proteasome chain 7, Proteasome subunit beta-1i, Really interesting new gene 12 protein | LMP2, PSMB6i, RING12
Primary ID P28065
Links - -
Type protein
Relations 1
Inhibitors carfilzomib
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png chemical inhibition PSMB9 0.8
Publications: 1 Organism: Homo Sapiens