Relation Results

Summary

Name TKT
Full Name Transketolase
Synonyms TK |
Primary ID P29401
Links - -
Type protein
Relations 9
Pathways Pentose phosphate pathway
Function Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine p ...
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Type: Score: Layout: SPV 
0.20.20.2850.80.80.20.80.2690.8VRK2TKTAKTAKT1D-ribofuranose 5-phosphate(2-)D-xylulose 5-phosphate(2-)FBXL6sedoheptulose 7-phosphateNFE2L2D-glyceraldehyde 3-phosphate(2-)

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ VRK2up-regulates activity img/direct-activation.png phosphorylation TKT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277842 Thr287 SKKKILAtPPQEDAP Homo sapiens HuH-7 Cell
pmid sentence
Mechanistically, VRK2 promoted Thr287 phosphorylation of TKT and then recruited FBXL6 to promote TKT ubiquitination and activation. 
Publications: 1 Organism: Homo Sapiens
+ AKTup-regulates activity img/direct-activation.png phosphorylation TKT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265102 Thr382 GCATRNRtVPFCSTF Homo sapiens HeLa Cell
pmid sentence
Akt phosphorylates TKT on Thr382, markedly enhancing enzyme activity and increasing carbon flow through the nonoxidative PPP, thereby increasing purine synthesis.
Publications: 1 Organism: Homo Sapiens
+ AKT1up-regulates activity img/direct-activation.png phosphorylation TKT 0.285
Identifier Residue Sequence Organism Cell Line
SIGNOR-265101 Thr382 GCATRNRtVPFCSTF Homo sapiens HeLa Cell
pmid sentence
Akt phosphorylates TKT on Thr382, markedly enhancing enzyme activity and increasing carbon flow through the nonoxidative PPP, thereby increasing purine synthesis.
Publications: 1 Organism: Homo Sapiens
+ TKTdown-regulates quantity img/direct_inhibition.png chemical modification D-ribofuranose 5-phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267086 Homo sapiens
pmid sentence
Transketolase (TK, EC 2.2.1.1) is the key rate-limiting enzyme of the non-oxidative branch of the pentose phosphate pathway of carbohydrate transformation. TKs (with the exception of the enzymes of mammalian origin) are characterized by broad substrate specificity. Xylulose 5-phosphate (X5P), fructose 6-phosphate (F6P), erythrulose 4-phosphate, and sedoheptulose 7-phosphate are typical donor substrates of TK; ribose 5-phosphate (R5P), glyceraldehyde 3-phosphate (G3P), and erythrose 4-phosphate are typical acceptor substrates.
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
+ TKTdown-regulates quantity img/direct_inhibition.png chemical modification D-xylulose 5-phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267085 Homo sapiens
pmid sentence
Transketolase (TK, EC 2.2.1.1) is the key rate-limiting enzyme of the non-oxidative branch of the pentose phosphate pathway of carbohydrate transformation. TKs (with the exception of the enzymes of mammalian origin) are characterized by broad substrate specificity. Xylulose 5-phosphate (X5P), fructose 6-phosphate (F6P), erythrulose 4-phosphate, and sedoheptulose 7-phosphate are typical donor substrates of TK; ribose 5-phosphate (R5P), glyceraldehyde 3-phosphate (G3P), and erythrose 4-phosphate are typical acceptor substrates.
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
+ FBXL6up-regulates activity img/direct-activation.png ubiquitination TKT 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277843 Homo sapiens HuH-7 Cell
pmid sentence
Mechanistically, VRK2 promoted Thr287 phosphorylation of TKT and then recruited FBXL6 to promote TKT ubiquitination and activation. 
Publications: 1 Organism: Homo Sapiens
+ TKTup-regulates quantity img/direct-activation.png chemical modification sedoheptulose 7-phosphate 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267087 Homo sapiens
pmid sentence
Transketolase (TK, EC 2.2.1.1) is the key rate-limiting enzyme of the non-oxidative branch of the pentose phosphate pathway of carbohydrate transformation. TKs (with the exception of the enzymes of mammalian origin) are characterized by broad substrate specificity. Xylulose 5-phosphate (X5P), fructose 6-phosphate (F6P), erythrulose 4-phosphate, and sedoheptulose 7-phosphate are typical donor substrates of TK; ribose 5-phosphate (R5P), glyceraldehyde 3-phosphate (G3P), and erythrose 4-phosphate are typical acceptor substrates.
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
+ NFE2L2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TKT 0.269
Identifier Residue Sequence Organism Cell Line
SIGNOR-267356 Homo sapiens
pmid sentence
We identified six genes involved in the PPP and NADPH production pathways as direct targets of Nrf2. To identify the target genes of NRF2 responsible for cell proliferation, we performed microarray analysis in A549 cells treated with NRF2 siRNA or control siRNA. We used three independent NRF2 siRNAs and selected genes whose expression levels were reduced to less than 66.7% of that of the control sample by all three siRNAs to minimize off-target effects (Table S1). In addition to the typical target genes of NRF2 encoding detoxifying enzymes and antioxidant proteins (cytoprotective genes), genes whose products are involved in the PPP (glucose-6-phosphate dehydrogenase [G6PD], phosphogluconate dehydrogenase [PGD], transketolase [TKT], and transaldolase 1 [TALDO1]) and de novo nucleotide synthesis (phosphoribosyl pyrophosphate amidotransferase [PPAT] and methylenetetrahydrofolate dehydrogenase 2 [MTHFD2]) were decreased by the NRF2 knockdown (Figure 1B). Genes encoding enzymes for NADPH synthesis (malic enzyme 1 [ME1] and isocitrate dehydrogenase 1 [IDH1]) were also decreased (Figure 1B). We also confirmed the reduction of the enzyme proteins encoded by these genes in the NRF2-knockdown cells (Figure 1C).
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
+ TKTup-regulates quantity img/direct-activation.png chemical modification D-glyceraldehyde 3-phosphate(2-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267088 Homo sapiens
pmid sentence
Transketolase (TK, EC 2.2.1.1) is the key rate-limiting enzyme of the non-oxidative branch of the pentose phosphate pathway of carbohydrate transformation. TKs (with the exception of the enzymes of mammalian origin) are characterized by broad substrate specificity. Xylulose 5-phosphate (X5P), fructose 6-phosphate (F6P), erythrulose 4-phosphate, and sedoheptulose 7-phosphate are typical donor substrates of TK; ribose 5-phosphate (R5P), glyceraldehyde 3-phosphate (G3P), and erythrose 4-phosphate are typical acceptor substrates.
Publications: 1 Organism: Homo Sapiens
Pathways:Pentose phosphate pathway
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