Relation Results

Summary

Name GTF2H1
Full Name General transcription factor IIH subunit 1
Synonyms Basic transcription factor 2 62 kDa subunit, BTF2 p62, General transcription factor IIH polypeptide 1, TFIIH basal transcription factor complex p62 subunit | BTF2
Primary ID P32780
Links - -
Type protein
Relations 3
Function Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleoti ...
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Type: Score: Layout: SPV 
0.4370.904GTF2H1E2F1TFIIH

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ GTF2H1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation E2F1 0.437
Identifier Residue Sequence Organism Cell Line
SIGNOR-251259 Ser403 PEEFISLsPPHEALD in vitro
pmid sentence
TFIIH-mediated phosphorylation of E2F-1 plays a role in triggering E2F-1 degradation during S phase. E2F-1 activation domain interacts with a kinase activity which phosphorylates two sites, Ser403 and Thr433, within the activation domain. We demonstrate that TFIIH is responsible for the E2F-1 phosphorylation observed in cell extracts and that endogenous E2F-1 interacts in vivo with p62, a component of TFIIH, during S phase.
Identifier Residue Sequence Organism Cell Line
SIGNOR-251260 Thr433 DCDFGDLtPLDF in vitro
pmid sentence
TFIIH-mediated phosphorylation of E2F-1 plays a role in triggering E2F-1 degradation during S phase. E2F-1 activation domain interacts with a kinase activity which phosphorylates two sites, Ser403 and Thr433, within the activation domain. We demonstrate that TFIIH is responsible for the E2F-1 phosphorylation observed in cell extracts and that endogenous E2F-1 interacts in vivo with p62, a component of TFIIH, during S phase.
Publications: 2 Organism: In Vitro
+ GTF2H1form complex img/form-complex.png binding TFIIH 0.904
Identifier Residue Sequence Organism Cell Line
SIGNOR-269316 Homo sapiens
pmid sentence
Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair.|The TFIIH core complex is composed of the seven subunits XPB, XPD, p62, p52, p44, p34, and p8, and is the form of TFIIH active in DNA repair|and additionally the CdK activating kinase (CAK) complex, which harbors the kinase activity of CDK7 as well as the Cyclin H and MAT1 subunits
Publications: 1 Organism: Homo Sapiens
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