4.0
Summary
| Name |  CYP2C18
|
| Full Name | Cytochrome P450 2C18 |
| Synonyms | CYPIIC18, Cytochrome P450-6b/29c | |
| Primary ID | P33260 |
| Links |  -  -  |
| Type | protein |
| Relations | 0 |
| Function | A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). |