3.0
Summary
| Name |  HSPA9View Modifications |
| Full Name | Stress-70 protein, mitochondrial |
| Synonyms | 75 kDa glucose-regulated protein, GRP-75, Heat shock 70 kDa protein 9, Mortalin, MOT, Peptide-binding protein 74, PBP74 | GRP75, HSPA9B, mt-HSP70 |
| Primary ID | P38646 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TTK | up-regulates 
phosphorylation
|
HSPA9 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | HSPA9 | down-regulates activity 
binding
|
MVD | 0.349 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | HSPA9 | form complex 
binding
|
TIM23 complex | 0.678 |
| Publications: | 1 | |||
| + | HSPA9 | up-regulates activity
relocalization
|
iron-sulfur cluster | 0.8 |
| Publications: | 1 | |||