Summary

Name DDOST
Full Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Synonyms DDOST 48 kDa subunit, Oligosaccharyl transferase 48 kDa subunit | KIAA0115, OST48
Primary ID P39656
Links - -
Type protein
Relations 1
Function Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853).

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Relations

Regulator Mechanism target score ℹ
+ DDOSTform complex img/form-complex.png binding OST-B complex 0.758
Publications: 1 Organism: Homo Sapiens