Relation Results

Summary

Name PTGER3
Full Name Prostaglandin E2 receptor EP3 subtype
Synonyms PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, PGE2-R, Prostanoid EP3 receptor
Primary ID P43115
Links - -
Type protein
Relations 12
Function Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor c ...
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Type: Score: Layout: SPV 
0.3330.3180.4950.4460.280.4470.80.2710.4530.250.8PTGER3EGFRSRCGNB3GNG12GNAO1GNAI1prostaglandin E2(1-)GNAZGNAI3GNA12prostaglandin E2

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Relations
Regulator
Mechanism
target
score ℹ
+ PTGER3up-regulates quantity img/direct-activation.png relocalization EGFR 0.333
Identifier Residue Sequence Organism Cell Line
SIGNOR-278884 Homo sapiens A-549 Cell
pmid sentence
These results demonstrate that PGE2 -mediated EGFR nuclear translocation requires the EP3 receptor.
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates activity img/direct-activation.png binding SRC 0.318
Identifier Residue Sequence Organism Cell Line
SIGNOR-278885 Homo sapiens A-549 Cell
pmid sentence
These results clearly demonstrate that EP3 contributes to the activation of Src and its related cell growth in A549 cells treated with PGE2.
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates img/direct-activation.png binding GNB3 0.495
Identifier Residue Sequence Organism Cell Line
SIGNOR-88192 Homo sapiens
pmid sentence
Ep3 receptor signals are primarily involved in adenylyl cyclase via g(i) activation, and in ca(2+)-mobilization through g(beta)(gamma) from g(i)
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates img/direct-activation.png binding GNG12 0.446
Identifier Residue Sequence Organism Cell Line
SIGNOR-88195 Homo sapiens Neuron
pmid sentence
Ep3 receptor signals are primarily involved in adenylyl cyclase via g(i) activation, and in ca(2+)-mobilization through g(beta)(gamma) from g(i)
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates activity img/direct-activation.png binding GNAO1 0.28
Identifier Residue Sequence Organism Cell Line
SIGNOR-256995 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates activity img/direct-activation.png binding GNAI1 0.447
Identifier Residue Sequence Organism Cell Line
SIGNOR-256716 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ prostaglandin E2(1-)up-regulates activity img/direct-activation.png chemical activation PTGER3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257571 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates activity img/direct-activation.png binding GNAZ 0.271
Identifier Residue Sequence Organism Cell Line
SIGNOR-257111 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates activity img/direct-activation.png binding GNAI3 0.453
Identifier Residue Sequence Organism Cell Line
SIGNOR-256859 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates activity img/direct-activation.png binding GNA12 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-257203 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ prostaglandin E2up-regulates img/direct-activation.png chemical activation PTGER3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-127738 Homo sapiens
pmid sentence
Pge2 is the ligand for four ep receptor subtypes termed ep1 to ep4.
Publications: 1 Organism: Homo Sapiens
+ PTGER3up-regulates img/direct-activation.png binding GNAI1 0.447
Identifier Residue Sequence Organism Cell Line
SIGNOR-88143 Homo sapiens
pmid sentence
Ep3 receptor signals are primarily involved in adenylyl cyclase via g(i) activation, and in ca(2+)-mobilization through g(beta)(gamma) from g(i)
Publications: 1 Organism: Homo Sapiens
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