Summary

Name PSMC4
Full Name 26S proteasome regulatory subunit 6B
Synonyms 26S proteasome AAA-ATPase subunit RPT3, MB67-interacting protein, MIP224, Proteasome 26S subunit ATPase 4, Tat-binding protein 7, TBP-7 | MIP224, TBP7
Primary ID P43686
Links - -
Type protein
Relations 2
Function Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PSMC4 0.291
Publications: 1
+ form complex img/form-complex.png binding 26S Proteasome 0.868
Publications: 1 Organism: Homo Sapiens