Relation Results

Summary

Name PHKA1
Full Name Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
Synonyms Phosphorylase kinase alpha M subunit | PHKA
Primary ID P46020
Links - -
Type protein
Relations 10
Pathways Glycogenolysis
Function Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

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Type: Score: Layout: SPV 
0.20.4270.6890.8510.320.320.2PHKA1PRKACAPHKG1PHKG2PRKACGPRKACBPKA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PHKA1up-regulates activity img/direct-activation.png phosphorylation PHKA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-250280 Ser1007 TGIMQLKsEIKQVEF in vitro
pmid sentence
Phk is activated in vitro by autophosphorylation. Ser1018 and at least three of the other six serine residues (Ser972, -985, and -1007) can be phosphorylated in vitro by Phk itself (autophosphorylation)
Identifier Residue Sequence Organism Cell Line
SIGNOR-250281 Ser972 KEFGVERsVRPTDSN in vitro
pmid sentence
Phk is activated in vitro by autophosphorylation. Ser1018 and at least three of the other six serine residues (Ser972, -985, and -1007) can be phosphorylated in vitro by Phk itself (autophosphorylation)
Identifier Residue Sequence Organism Cell Line
SIGNOR-250282 Ser985 SNVSPAIsIHEIGAV in vitro
pmid sentence
Phk is activated in vitro by autophosphorylation. Ser1018 and at least three of the other six serine residues (Ser972, -985, and -1007) can be phosphorylated in vitro by Phk itself (autophosphorylation)
Publications: 3 Organism: In Vitro
Pathways:Glycogenolysis
+ PRKACAup-regulates activity img/direct-activation.png phosphorylation PHKA1 0.427
Identifier Residue Sequence Organism Cell Line
SIGNOR-250026 Ser1018 QVEFRRLsISAESQS
pmid sentence
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. Ser1018 within this multiphosphorylation domain is phosphorylated by PKA and is a major site of regulatory phosphorylation in vivo
Identifier Residue Sequence Organism Cell Line
SIGNOR-267411 Homo sapiens
pmid sentence
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme.
Publications: 2 Organism: , Homo Sapiens
+ PHKA1down-regulates activity img/direct_inhibition.png binding PHKG1 0.689
Identifier Residue Sequence Organism Cell Line
SIGNOR-267405 Homo sapiens
pmid sentence
Phk is among the most complex of the protein kinases so far elucidated. It has one catalytic (gamma) subunit and three different regulatory (alpha, beta, and delta) subunits, a molecular mass of 1.3 X 106 daltons, and each holoenzyme molecule is presumed to contain four molecules of each subunit. The three regulatory subunits inhibit the phosphotransferase activity of the gamma subunit.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenolysis
+ PHKA1down-regulates activity img/direct_inhibition.png binding PHKG2 0.851
Identifier Residue Sequence Organism Cell Line
SIGNOR-267407 Homo sapiens
pmid sentence
Phk is among the most complex of the protein kinases so far elucidated. It has one catalytic (gamma) subunit and three different regulatory (alpha, beta, and delta) subunits, a molecular mass of 1.3 X 106 daltons, and each holoenzyme molecule is presumed to contain four molecules of each subunit. The three regulatory subunits inhibit the phosphotransferase activity of the gamma subunit.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenolysis
+ PRKACGdown-regulates activity img/direct_inhibition.png phosphorylation PHKA1 0.32
Identifier Residue Sequence Organism Cell Line
SIGNOR-267415 Homo sapiens
pmid sentence
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme.
Publications: 1 Organism: Homo Sapiens
+ PRKACBdown-regulates activity img/direct_inhibition.png phosphorylation PHKA1 0.32
Identifier Residue Sequence Organism Cell Line
SIGNOR-267413 Homo sapiens
pmid sentence
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme.
Publications: 1 Organism: Homo Sapiens
+ PKAdown-regulates activity img/direct_inhibition.png phosphorylation PHKA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267409 Homo sapiens
pmid sentence
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycogenolysis
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