+ |
PHKA1 | up-regulates activity
phosphorylation
|
PHKA1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250280 |
Ser1007 |
TGIMQLKsEIKQVEF |
in vitro |
|
pmid |
sentence |
10487978 |
Phk is activated in vitro by autophosphorylation. Ser1018 and at least three of the other six serine residues (Ser972, -985, and -1007) can be phosphorylated in vitro by Phk itself (autophosphorylation) |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250281 |
Ser972 |
KEFGVERsVRPTDSN |
in vitro |
|
pmid |
sentence |
10487978 |
Phk is activated in vitro by autophosphorylation. Ser1018 and at least three of the other six serine residues (Ser972, -985, and -1007) can be phosphorylated in vitro by Phk itself (autophosphorylation) |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250282 |
Ser985 |
SNVSPAIsIHEIGAV |
in vitro |
|
pmid |
sentence |
10487978 |
Phk is activated in vitro by autophosphorylation. Ser1018 and at least three of the other six serine residues (Ser972, -985, and -1007) can be phosphorylated in vitro by Phk itself (autophosphorylation) |
|
Publications: |
3 |
Organism: |
In Vitro |
Pathways: | Glycogenolysis |
+ |
PRKACA | up-regulates activity
phosphorylation
|
PHKA1 |
0.418 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250026 |
Ser1018 |
QVEFRRLsISAESQS |
|
|
pmid |
sentence |
10487978 |
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. Ser1018 within this multiphosphorylation domain is phosphorylated by PKA and is a major site of regulatory phosphorylation in vivo |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267411 |
|
|
Homo sapiens |
|
pmid |
sentence |
10487978 |
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. |
|
Publications: |
2 |
Organism: |
, Homo Sapiens |
+ |
PKA | down-regulates activity
phosphorylation
|
PHKA1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267409 |
|
|
Homo sapiens |
|
pmid |
sentence |
10487978 |
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Glycogenolysis |
+ |
PRKACG | down-regulates activity
phosphorylation
|
PHKA1 |
0.307 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267415 |
|
|
Homo sapiens |
|
pmid |
sentence |
10487978 |
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKACB | down-regulates activity
phosphorylation
|
PHKA1 |
0.307 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267413 |
|
|
Homo sapiens |
|
pmid |
sentence |
10487978 |
Phosphorylation of the alpha and beta subunits by the 3',5'-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) also relieves inhibition of the gamma subunit and thereby activates the enzyme. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PHKA1 | down-regulates activity
binding
|
PHKG1 |
0.68 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267405 |
|
|
Homo sapiens |
|
pmid |
sentence |
10487978 |
Phk is among the most complex of the protein kinases so far elucidated. It has one catalytic (gamma) subunit and three different regulatory (alpha, beta, and delta) subunits, a molecular mass of 1.3 X 106 daltons, and each holoenzyme molecule is presumed to contain four molecules of each subunit. The three regulatory subunits inhibit the phosphotransferase activity of the gamma subunit. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Glycogenolysis |
+ |
PHKA1 | down-regulates activity
binding
|
PHKG2 |
0.85 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267407 |
|
|
Homo sapiens |
|
pmid |
sentence |
10487978 |
Phk is among the most complex of the protein kinases so far elucidated. It has one catalytic (gamma) subunit and three different regulatory (alpha, beta, and delta) subunits, a molecular mass of 1.3 X 106 daltons, and each holoenzyme molecule is presumed to contain four molecules of each subunit. The three regulatory subunits inhibit the phosphotransferase activity of the gamma subunit. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Glycogenolysis |