Relation Results

Summary

Name NSF
Full Name Vesicle-fusing ATPase
Synonyms N-ethylmaleimide-sensitive fusion protein, NEM-sensitive fusion protein, Vesicular-fusion protein NSF
Primary ID P46459
Links - -
Type protein
Relations 5
Function Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from th ...
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Type: Score: Layout: SPV 
0.2340.3680.4140.726PRKCENSFLRRK2PTPN9SNAP25

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCEup-regulates activity img/direct-activation.png phosphorylation NSF 0.234
Identifier Residue Sequence Organism Cell Line
SIGNOR-278300 Ser460 MNRHIKAsTKVEVDM Homo sapiens
pmid sentence
PKCepsilon phosphorylation enhances the ATPase activity of NSF.|These results indicate that PKCepsilon phosphorylates NSF at both S460 and T461 in vitro.
Identifier Residue Sequence Organism Cell Line
SIGNOR-278299 Thr461 NRHIKAStKVEVDME Homo sapiens
pmid sentence
PKCepsilon phosphorylation enhances the ATPase activity of NSF.|These results indicate that PKC\u03b5 phosphorylates NSF at both S460 and T461 in vitro .
Publications: 2 Organism: Homo Sapiens
+ LRRK2up-regulates activity img/direct-activation.png phosphorylation NSF 0.368
Identifier Residue Sequence Organism Cell Line
SIGNOR-277196 Thr645 RKLLIIGtTSRKDVL Homo sapiens HEK-293T Cell
pmid sentence
LRRK2 phosphorylates full-length NSF at threonine 645 in the ATP binding pocket of D2 domain. Functionally, NSF phosphorylated by LRRK2 displays enhanced ATPase activity and increased rate of SNARE complex disassembling.
Publications: 1 Organism: Homo Sapiens
+ PTPN9down-regulates img/direct_inhibition.png dephosphorylation NSF 0.414
Identifier Residue Sequence Organism Cell Line
SIGNOR-128348 Tyr83 QEIEVSLyTFDKAKQ Homo sapiens
pmid sentence
Our results suggest that the molecular mechanism by which ptp-meg2 promotes secretory vesicle fusion involves the local release of nsf from a tyrosine-phosphorylated, inactive state.
Publications: 1 Organism: Homo Sapiens
+ NSFdown-regulates activity img/direct_inhibition.png binding SNAP25 0.726
Identifier Residue Sequence Organism Cell Line
SIGNOR-263974 Homo sapiens Neuron
pmid sentence
NSF is an important regulator of SNARE assembly/disassembly. NSF binds to SNAP-25, while in complex with other SNAREs, and hydrolyzes adenosine triphosphate to disassemble the SNARE complex down to monomers
Publications: 1 Organism: Homo Sapiens
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