Summary

Name NOTCH1
Full Name Neurogenic locus notch homolog protein 1
Synonyms Notch 1, hN1, Translocation-associated notch protein TAN-1 | TAN1
Primary ID P46531
Links - -
Type protein
Relations 133
Pathways Acute Myeloid Leukemia, FAP: Notch, FLT3-ITD in AML, FLT3-ITD signaling, NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling, Rett syndrome
Function Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png hydroxylation NOTCH1 0.568
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination NOTCH1 0.431
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png acetylation NOTCH1 0.424
Publications: 4 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NOTCH1 0.533
Publications: 3 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NOTCH1 0.244
Publications: 3 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NOTCH1 0.305
Publications: 3 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NOTCH1 0.382
Publications: 3 Organism: In Vitro
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, NOTCH Signaling
+ up-regulates img/direct-activation.png binding NOTCH1 0.922
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.264
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.613
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis, Rett syndrome
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NOTCH1 0.293
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, Rett syndrome
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.676
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.836
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png glycosylation, binding NOTCH1 0.747
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates activity img/direct_inhibition.png binding NOTCH1 0.308
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ADAM19 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.631
Publications: 3 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates activity img/direct-activation.png cleavage NOTCH1 0.663
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding NOTCH1 0.653
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.533
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.385
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding NOTCH1 0.608
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL2RA 0.297
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.757
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding NOTCH1 0.498
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.422
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.295
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FABP7 0.527
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.393
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.384
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png ubiquitination NOTCH1 0.772
Publications: 3 Organism: Drosophila Melanogaster, Mus Musculus, Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ down-regulates img/indirect_inhibition.png Neurogenesis 0.7
Publications: 1 Organism: Mus Musculus
Pathways:Retinoic acid Signaling, Rett syndrome
+ up-regulates img/direct-activation.png ubiquitination NOTCH1 0.487
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates img/direct-activation.png acetylation NOTCH1 0.587
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NOTCH1 0.474
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ form complex img/form-complex.png binding RBPJ/NOTCH 0.949
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling
+ down-regulates img/direct_inhibition.png deacetylation NOTCH1 0.429
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.262
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png glycosylation NOTCH1 0.589
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NOTCH1 0.377
Publications: 4 Organism: Homo Sapiens, In Vitro
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.469
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates img/direct-activation.png binding NOTCH1 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NOTCH1 0.351
Publications: 3 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TCF12 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TCFL5 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.484
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage NOTCH1 0.728
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding ZMIZ1 0.462
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HOXA5 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.402
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding NOTCH1 0.611
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling
+ down-regulates img/direct_inhibition.png binding TCF3 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage NOTCH1 0.788
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.268
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.323
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.585
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HEYL 0.592
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.458
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.324
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.466
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.63
Publications: 1 Organism: Drosophila Melanogaster
Pathways:NOTCH Signaling
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.568
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.317
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.462
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NOTCH1 0.789
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding SNW1 0.585
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH1 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERBB2 0.504
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png BMPR1A/1B/2 0.359
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.922
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling, Rett syndrome
+ up-regulates img/direct-activation.png binding NOTCH1 0.733
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYC 0.653
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, NOTCH Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIN1 0.393
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.384
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.344
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
Pathways:Rett syndrome
+ up-regulates img/direct-activation.png binding NOTCH1 0.556
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB1 0.386
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates quantity by expression img/indirect-activation.png PAX7 0.397
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle, Satellite Cell
Pathways:Acute Myeloid Leukemia, NOTCH Signaling and Myogenesis
+ down-regulates quantity img/indirect_inhibition.png transcriptional regulation NOTCH1 0.379
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LFNG 0.747
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL11B 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.765
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Retinoic acid Signaling
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HES1 0.762
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, NOTCH Signaling, NOTCH Signaling and Myogenesis, Retinoic acid Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HEY1 0.763
Publications: 1 Organism: Mus Musculus
Pathways:NOTCH Signaling, NOTCH Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.432
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NOTCH1 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.632
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png ubiquitination NOTCH1 0.63
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates activity img/direct-activation.png cleavage NOTCH1 0.773
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization HIF1A 0.635
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates img/direct-activation.png relocalization NOTCH1 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding NOTCH1 0.295
Publications: 1 Organism: Mus Musculus
Tissue: MEF Cell
+ up-regulates img/direct-activation.png binding NOTCH1 0.389
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB2 0.292
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.709
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination NOTCH1 0.629
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates img/direct-activation.png binding RBPJ 0.949
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png glycosylation NOTCH1 0.389
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL7R 0.325
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.439
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.585
Publications: 1 Organism: In Vitro
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates img/indirect-activation.png NOTCH1 0.62
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
Pathways:Acute Myeloid Leukemia