| + |
MTOR | down-regulates activity 
phosphorylation
|
DAP |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259813 |
Ser3 |
DQEWESPsPPKPTVF |
Homo sapiens |
|
| pmid |
sentence |
| 20537536 |
A critical step in autophagy induction comprises the inactivation of a key negative regulator of the process, the Ser/Thr kinase mammalian target of rapamycin (mTOR). Here we identify death-associated protein 1 (DAP1) as a novel substrate of mTOR that negatively regulates autophagy. Mapping of the phosphorylation sites and analysis of phosphorylation mutants indicated that DAP1 is functionally silenced in growing cells through mTOR-dependent phosphorylations on Ser3 and Ser51. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259812 |
Ser51 |
DQEWESPsPPKPTVF |
Homo sapiens |
|
| pmid |
sentence |
| 20537536 |
A critical step in autophagy induction comprises the inactivation of a key negative regulator of the process, the Ser/Thr kinase mammalian target of rapamycin (mTOR). Here we identify death-associated protein 1 (DAP1) as a novel substrate of mTOR that negatively regulates autophagy. Mapping of the phosphorylation sites and analysis of phosphorylation mutants indicated that DAP1 is functionally silenced in growing cells through mTOR-dependent phosphorylations on Ser3 and Ser51. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
DAP
- 
- 